merck millipore,默克密理愽
  • merck millipore,默克密理博,AG798,IkBβ, control peptide for AB3002

  • merck millipore,默克密理博,AG798,IkBβ, control peptide for AB3002

    产品名称：IkBβ, control peptide for AB3002
    产品型号：AG798
    Control peptide from IkappaBbeta near the C-terminus.

    merck millipore,默克密理博,AG798,IkBβ, control peptide for AB3002

  • 产品介绍
  • merck millipore,默克密理博,AG798,IkBβ, control peptide for AB3002

    描述
    产品目录编号 AG798
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 IkBβ, control peptide for AB3002
    概述 Control peptide from IkappaBbeta near the C-terminus.
    产品信息
    演示 Liquid in 0.02M Potassium Phosphate with 0.15M Sodium Chloride and 0.01% sodium azide.
    应用
    应用 Control peptide from IkappaBbeta near the C-terminus.
    主要应用
    • Cell Function Assay
    应用说明 For use in blocking the reactivity of AB3002. Suggested concentration is 1 μg per 1 μL of antiserum per assay.

    Optimal working dilution must be determined by the end user.
    生物信息
    浓缩 1 mg/mL
    品种 Human
    Entrez基因编号
    • NM_001556.1
    Entrez基因汇总 NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]
    基因符号
    • EC 2.7.11.10
    • IKBKB
    • IKK-B
    • IKK-beta
    • NFKBIKB
    • IKK2
    • FLJ40509
    • IkBKB
    • IKKB
    • MGC131801
    UniProt编号
    • O14920
    UniProt汇总 FUNCTION: SwissProt: O14920 # Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3 (By similarity).
    SIZE: 756 amino acids; 86564 Da
    SUBUNIT: Preferentially found as a heterodimer with IKK-alpha but also as a homodimer. Directly interacts with IKK-gamma/NEMO and TRPC4AP. The tripartite complex can also bind to MEKK1, MAP3K14/NIK, IKAP and IKB-alpha-p65-p50 complex. Phosphorylated IKB-alpha is further released from the complex. Found in a complex composed of NCOA2, NCOA3, IKKA, IKBKG and CREBBP. Interacts with SQSTM1 through PRKCZ or PRKCI. Forms an NGF-induced complex with IKBKB, PRKCI and TRAF6. May interact with MAVS/IPS1. Interacts with NALP2. Interacts with Yersinia yopJ.
    SUBCELLULAR LOCATION: Cytoplasm.
    TISSUE SPECIFICITY: Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood.
    PTM: Upon cytokine stimulation, phosphorylated on Ser-177 and Ser- 181 by MEKK1 and/or MAP3K14/NIK; which enhances activity. Once activated, autophosphorylates on the C-terminal serine cluster; which decreases activity and prevents prolonged activation of the inflammatory response. & Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, which blocks the I-kappa-B signaling pathway.
    SIMILARITY: SwissProt: O14920 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. IkappaB kinase subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AG798,IkBβ, control peptide for AB3002

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