merck millipore,默克密理愽
  • merck millipore,默克密理博,238803,Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem

  • merck millipore,默克密理博,238803,Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem

    产品名称：Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem
    产品型号：238803
    The Cdk2 Inhibitor III, also referenced under CAS 199986-75-9, controls the biological activity of Cdk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applica More>>

    merck millipore,默克密理博,238803,Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,238803,Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₂₈N₆O₃199986-75-9
    描述
    概述 A cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC50 = ~1.25-20 µM) in vitro and prevent neointima formation in vivo.
    产品目录编号 238803
    品牌系列 Calbiochem®
    同义词 2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine, CVT-313
    参考
    参考 Bhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
    Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.
    产品信息
    CAS号 199986-75-9
    具有ATP竞争性 Y
    声明 Sold under license of U.S. Patents 6,617,331 and 6,803,371.
    形式 White solid
    Hill配方 C₂₀H₂₈N₆O₃
    化学配方 C₂₀H₂₈N₆O₃
    Molar Mass 400.5
    可逆 Y
    结构配方图像
    生物信息
    主靶 Cdk2/A, Cdk2/E
    主靶IC50 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Carcinogenic / Teratogenic
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,238803,Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem

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