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merck millipore,默克密理博,46-604MAG,MILLIPLEX MAP Caspase 3 (Active) Magnetic Bead MAPmate - Cell Signaling Single Plex
产品名称：MILLIPLEX MAP Caspase 3 (Active) Magnetic Bead MAPmate - Cell Signaling Single Plex
产品型号：46-604MAG
This MILLIPLEX MAP Caspase 3 (Active) Magnetic Bead MAPmate Cell Signaling Single Plexhas the analyte Caspase 3 (Active).
merck millipore,默克密理博,46-604MAG,MILLIPLEX MAP Caspase 3 (Active) Magnetic Bead MAPmate - Cell Signaling Single Plex
- 产品介绍
- merck millipore,默克密理博,46-604MAG,MILLIPLEX MAP Caspase 3 (Active) Magnetic Bead MAPmate - Cell Signaling Single Plex
重要规格表
可用的分析物 品种反应性 主要应用 检测方法 Caspase 3 (Active) M, H Mplex Luminex xMAP 描述 产品目录编号 46-604MAG 商名 - MILLIPLEX
描述 MILLIPLEX MAP Caspase 3 (Active) Magnetic Bead MAPmate - Cell Signaling Single Plex 背景信息 Caspase 3 (Active)
• A member of the Cysteine-aspartic acid protease (Caspase) family
• Caspases exist as inactive proenzymes that undergo proteolytic processing at aspartic residues to produce two subunits that dimerize to form the active enzyme
• Associated with brain development, dysfunction and possibly stem cell differentiation产品信息 检测方法 Luminex xMAP 配置 Single Plex 板面类型 Cell Signaling 应用 应用 This MILLIPLEX MAP Caspase 3 (Active) Magnetic Bead MAPmate Cell Signaling Single Plexhas the analyte Caspase 3 (Active). 主要应用 - Multiplexing
应用说明 • An overnight (4°C) incubation is recommended for best results
• These assays require 25 µL diluted cell lysate per well
• Please consult the buffer compatibility chart or protocol for appropriate buffer choice
• 1 - 25 μg cell lysate/well (recommended starting concentration is 20 μg生物信息 品种反应性 MouseHuman 可用的分析物 - Caspase 3 (Active)
Entrez基因编号 - NM_032991.2
- NM_004346.3
Entrez基因汇总 This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. 基因符号 - CPP32
- CASP3
- apopain
- procaspase3
- CPP-32
- Apopain
- Yama
- CASP-3
- CPP32B
- SCA-1
UniProt编号 - P42574
UniProt汇总 FUNCTION: SwissProt: P42574 # Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
SIZE: 277 amino acids; 31608 Da
SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
PTM: Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.
SIMILARITY: SwissProt: P42574 ## Belongs to the peptidase C14 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Recommended storage for kit components is 2 - 8°C 包装信息 数量 96-well plate
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