merck millipore,默克密理愽
  • merck millipore,默克密理博,475825,mitoNEET Inhibitor NL-1, Thiazolidinedione - Calbiochem

  • merck millipore,默克密理博,475825,mitoNEET Inhibitor NL-1, Thiazolidinedione - Calbiochem

    产品名称：mitoNEET Inhibitor NL-1, Thiazolidinedione - Calbiochem
    产品型号：475825
    The mitoNEET Inhibitor NL-1, Thiazolidinedione controls the biological activity of mitoNEET.

    merck millipore,默克密理博,475825,mitoNEET Inhibitor NL-1, Thiazolidinedione - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,475825,mitoNEET Inhibitor NL-1, Thiazolidinedione - Calbiochem

    重要规格表

    经验配方
    C₁₈H₂₅NO₃S
    描述
    概述 A cell-permeable, thiazolidinedione (TZD) that acts as an inhibitor of MitoNEET (IC50 = 0.9 µM) in competition with rosiglitazone and pioglitazone, in liver mitochondrial suspensions. In pharmacological studies, it was found to alter isolated mitochondrial complex I respiration with an IC50 of 2.4 µM and inhibited State III respiration up to 45%. Furthermore, this compound (6-25 µM) is shown to dose-dependently reduce lactate-dehydrogenase release in SH-SY5Y cultures, leading to a 40% decrease in rotenone-induced cell-death.
    产品目录编号 475825
    品牌系列 Calbiochem®
    同义词 5-(3,5-di-tert-butyl-4-hydroxybenzyl)-4-hydroxythiazol-2(5H)-one
    参考
    参考 Geldenhuys, W.J., et al. 2009. Bioorg Med Chem Lett. 3, 819.
    Giles, R.G., et al. 2000. Tetrahedron 56, 4531.
    产品信息
    形式 Yellow solid
    Hill配方 C₁₈H₂₅NO₃S
    化学配方 C₁₈H₂₅NO₃S
    Molar Mass 335.46
    结构配方图像
    生物信息
    纯度 ≥ 98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,475825,mitoNEET Inhibitor NL-1, Thiazolidinedione - Calbiochem

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