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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN327 描述 Anti-SCRAPPER Antibody Alternate Names - FBL20
- F-box
- Leucine rich repeat protein 20
- FBXL20
- FBl2
背景信息 Members of the F-box protein family, such as SCRAPPER, are characterized by an approximately 40-amino acid F-box motif. SCRAPPER is selectively expressed in the brain, broadly expressed within the mouse CNS, and is abundant at the presynaptic membrane. It has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. SCRAPPER is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check. 产品信息 格式 Affinity Purified 控制 - Human spleen tissue lysate
演示 Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide. 应用 应用 This SCRAPPER antibody is validated for use in WB & IHC for the detection of the SCRAPPER protein. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Western Blot Analysis: 1 µg/mL from a representative lot detected SCRAPPER in 10 µg/mL of RAW264.7 cell lysate.
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected SCRAPPER in human midbrain tissue.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human SCRAPPER. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human 抗体类型 Polyclonal Antibody 基因符号 - SCRAPPER
- FBXL20
纯化方法 Antigen Affinity purified UniProt编号 - Q96IG2
产品使用声明 质量保证 Evaluated by Western Blot in human spleen tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected SCRAPPER in 10 µg/mL of human spleen tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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