merck millipore,默克密理博,14-643,MRCKβ Protein, active, 10 µg

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merck millipore,默克密理博,14-643,MRCKβ Protein, active, 10 µg
产品名称：MRCKβ Protein, active, 10 µg
产品型号：14-643
Active, N-terminal His6-tagged, recombinant, human MRCKb amino acids 1-473, for use in Kinase Assays.

merck millipore,默克密理博,14-643,MRCKβ Protein, active, 10 µg

产品介绍

merck millipore,默克密理博,14-643,MRCKβ Protein, active, 10 µg

描述
产品目录编号	14-643
品牌系列	Upstate
商名	Upstate
描述	MRCKβ Protein, active, 10 µg
概述	N-terminal His6-tagged, recombinant, human MRCKb amino acids 1-473

应用
应用	Active, N-terminal His6-tagged, recombinant, human MRCKb amino acids 1-473, for use in Kinase Assays.
主要应用	Kinase Assay

生物信息
来源	human MRCKb amino acids 1-473, expressed by baculovirus in Sf21 cells
品种	Human
特异活性	For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez基因编号	NM_006035.3
Entrez基因汇总	This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization.
基因符号	MRCKB CDC42BPB KIAA1124
蛋白靶	MRCKβ
纯化方法	Ni²⁺/NTA-agarose
靶子系列	AGC
UniProt编号	Q9Y5S2
UniProt汇总	FUNCTION: SwissProt: Q9Y5S2 # May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). COFACTOR: Magnesium (By similarity). SIZE: 1711 amino acids; 194315 Da SUBUNIT: Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42 (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). TISSUE SPECIFICITY: Expressed in all tissues examined, with high levels in heart, brain, placenta and lung. SIMILARITY: SwissProt: Q9Y5S2 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 CNH domain. & Contains 1 CRIB domain. & Contains 1 PH domain. & Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 protein kinase domain.

产品使用声明
质量保证	routinely evaluated by phosphorylation of S6 Kinase/Rsk2 Substrate Peptide 2
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	6 months at -70°C

包装信息
数量	10 µg

merck millipore,默克密理博,14-643,MRCKβ Protein, active, 10 µg

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