merck millipore,默克密理博,MABT66,Anti-ILK Antibody, clone EP1593Y rabbit monoclonal

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	IHC, WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABT66
描述	Anti-ILK Antibody, clone EP1593Y rabbit monoclonal
Alternate Names	p59ILK integrin-linked kinase P59 DKFZp686F1765 59 kDa serine/threonine-protein kinase
背景信息	Integrin-linked kinase (ILK) is a key cytoplasmic plaque protein involved in the mediation of integrin functions. It plays a key role as a regulator during cell survival, cell proliferation, cell migration, and cell to cell adhesion (1). ILK links integrins to the actin cytoskeleton, allowing transduction of signals through integrins to the extracellular matrix (ECM). Also, ILK has been linked to the regulation of smooth contraction and cell motility in non-muscle cells through phosphorylation of myosin (2). Irregular activity level of ILK has been linked to expression of certain tumor. ILK overexpression caused by inactivating mutation in tumor suppressors (e.g. PTEN and APC) lead to tumor formation in transgenic mouse. Up-regulated ILK expression and activity are seen in Ewings scaromas, colorectal cancers, and late staged prostate cancers (3).

产品信息
格式	Unpurified
控制	COS cell lysate
演示	Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.18 M NaCl containing 40% Glycerol, 0.25% sodium azide, 0.25 mM EDTA, 25 mM Citric Acid, and 0.05% BSA.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-ILK Antibody, clone EP1593Y Rabbit is an antibody against ILK for use in WB, IH.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: 1:50-100 dilution from a previous lot detected ILK in human heart muscle.

生物信息
免疫原品种	Synthetic peptide corresponding to residues near the N-terminus of human ILK.
克隆	EP1593Y
宿主	Rabbit
特异性	The antibody recognizes ILK at the N-terminus.
品种反应性	RatHumanMouse
Species Reactivity Note	Proven to react with human, mouse, and rat.
抗体类型	Monoclonal Antibody
Entrez基因编号	Q13418
基因符号	ILK2 ILK-1 ILK1 ILK-2 EC 2.7.11.1
纯化方法	Unpurified
UniProt编号	Q13418

产品使用声明
质量保证	Evaluated by Western Blot in COS cell lysate. Western Blot Analysis: 1:2,000-10,000 dilution of the antibody was used to detect ILK in COS lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.

包装信息
数量	100 µL

merck millipore,默克密理博,MABT66,Anti-ILK Antibody, clone EP1593Y rabbit monoclonal

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