merck millipore,默克密理愽
  • merck millipore,默克密理博,05-478,Anti-erbB-4/HER-4 Antibody, clone H4.72.8

  • merck millipore,默克密理博,05-478,Anti-erbB-4/HER-4 Antibody, clone H4.72.8

    产品名称：Anti-erbB-4/HER-4 Antibody, clone H4.72.8
    产品型号：05-478
    This Anti-erbB-4/HER-4 Antibody, clone H4.72.8 is validated for use in FC, IP, NEUT for the detection of erbB-4/HER-4.

    merck millipore,默克密理博,05-478,Anti-erbB-4/HER-4 Antibody, clone H4.72.8

  • 产品介绍
  • merck millipore,默克密理博,05-478,Anti-erbB-4/HER-4 Antibody, clone H4.72.8

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-478
    Replaces 04-348
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-erbB-4/HER-4 Antibody, clone H4.72.8
    产品信息
    格式 Purified
    演示 10mM PBS, pH 7.4
    应用
    应用 This Anti-erbB-4/HER-4 Antibody, clone H4.72.8 is validated for use in FC, IP, NEUT for the detection of erbB-4/HER-4.
    主要应用
    • Flow Cytometry
    应用说明 Not recommended for western blot.
    生物信息
    免疫原品种 Extracellular domain of recombinant human c-erbB-4/HER-4
    克隆 clone H4.72.8
    宿主 Mouse
    特异性 c-erbB-4/HER-4 but not EGF receptor, c-erbB-2/HER-2, or c-erbB-3/HER-3
    同种型 IgG2a
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_005235
    Entrez基因汇总 This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
    基因符号
    • MDA-BF-1
    • ERBB3
    • c-erbB-3
    • c-erbB3
    • erbB-3
    • p180-ErbB3
    • p85-sErbB3
    • p45-sErbB3
    • ErbB-3
    • erbB3-S
    • MGC88033
    • HER3
    纯化方法 Protein A chromatography
    UniProt编号
    • P21860
    UniProt汇总 FUNCTION: SwissProt: P21860 # Binds and is activated by neuregulins and NTAK.
    SIZE: 1342 amino acids; 148098 Da
    SUBUNIT: Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5 and PA2G4.
    SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
    TISSUE SPECIFICITY: Epithelial tissues and brain.
    DOMAIN: SwissProt: P21860 The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
    PTM: Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (By similarity).
    DISEASE: SwissProt: P21860 # Overexpressed in a subset of human mammary tumors. & Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.
    SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by immunoprecipitationof c-erbB4/HER 4 from heregulin stimulated MDA-MB453 cells, and subsequently immunobloted with anti-Phosphotyrosine (Catalog #05-321)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-478,Anti-erbB-4/HER-4 Antibody, clone H4.72.8

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