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merck millipore,默克密理博,ABE62,Anti-MYSM1/2A-DUB Antibody
产品名称：Anti-MYSM1/2A-DUB Antibody
产品型号：ABE62
Anti-MYSM1/2A-DUB Antibody is a Rabbit Polyclonal Antibody for detection of MYSM1/2A-DUB also known as Histone H2A deubiquitinase MYSM1 & has been validated in WB.
merck millipore,默克密理博,ABE62,Anti-MYSM1/2A-DUB Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 ABE62 描述 Anti-MYSM1/2A-DUB Antibody Alternate Names - Myb-like, SWIRM and MPN domain-containing protein 1
- Histone H2A deubiquitinase MYSM1
- 2A-DUB
背景信息 Histone H2A deubiquitinase MYSM, often referred to as 2A-DUB is metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A. 2A-DUB regulates transcription by coordinating histone acetylation and deubiquitination, and destabilizing the association of linker histone H1 with nucleosomes. The 2A-DUB mechanism may just be one of many H2A ubiquitination proteins that have the ability to regulate transcription. 2A-DUB is also essential for cell cycle progression and gene expression. 产品信息 格式 Serum 控制 - NIH/3T3 cell lysate
演示 Rabbit polyclonal serum containing 0.05% sodium azide. 应用 应用 Anti-MYSM1/2A-DUB Antibody is a Rabbit Polyclonal Antibody for detection of MYSM1/2A-DUB also known as Histone H2A deubiquitinase MYSM1 & has been validated in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Recombinant protein corresponding to human of MYSM1. 宿主 Rabbit 品种反应性 MouseHuman Species Reactivity Note Demonstrated to react with Human and Mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001078956
基因符号 - KIAA1915
- MYSM1
纯化方法 Unpurified UniProt编号 - Q5VVJ2
UniProt汇总 FUNCTION: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
SUBUNIT STRUCTURE: Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones.
SUBCELLULAR LOCATION: Nucleus
DOMAIN: Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA.
POST-TRANSLATIONAL MODIFICATION: Phosphorylated upon DNA damage, probably by ATM or ATR.
SEQUENCE SIMILARITIES: Belongs to the peptidase M67A family. MYSM1 subfamily. Contains 1 MPN (JAB/Mov34) domain. Contains 1 SANT domain. Contains 1 SWIRM domain.
SEQUENCE CAUTION: The sequence BAB67808.1 differs from that shown. Reason: Erroneous initiation. The sequence BAG54377.1 differs from that shown. Reason: Erroneous initiation.产品使用声明 质量保证 Evaluated by Western Blot in NIH/3T3 cell lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected MYSM1 on 10 µg of NIH/3T3 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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