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品种反应性 主要应用 宿主 格式 抗体类型 H, B WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-556 品牌系列 Upstate
商名 - Upstate
描述 Anti-Kip2 Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl and 0.05% sodium azide 应用 应用 Detect Kip2 with Anti-Kip2 Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 15 amino acid synthetic peptide (CGVGSVEQTPRKRLR) corresponding to amino acids 303-316 of human Kip2 宿主 Rabbit 特异性 Kip2 同种型 IgG 品种反应性 HumanBovine 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000076
Entrez基因汇总 The protein encoded by this gene is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. 基因符号 - WBS
- CDKN1C
- BWS
- KIP2
- BWCR
- p57
- p57KIP2
- P57
纯化方法 Protein A chromatography UniProt编号 - P49918
UniProt汇总 FUNCTION: SwissProt: P49918 # Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life.
SIZE: 316 amino acids; 32177 Da
SUBCELLULAR LOCATION: Nucleus (By similarity).
TISSUE SPECIFICITY: Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.
DISEASE: SwissProt: P49918 # Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors. & Defects in CDKN1C are involved in tumor formation.
SIMILARITY: SwissProt: P49918 ## Belongs to the CDI family.产品使用声明 质量保证 routinely evaluated by immunoblot on HeLa nuclear extract or bovine brain nuclear extract 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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