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merck millipore,默克密理博,04-855,Anti-GluR1 Antibody, clone C3T, rabbit monoclonal
产品名称：Anti-GluR1 Antibody, clone C3T, rabbit monoclonal
产品型号：04-855
Anti-GluR1 Antibody, clone C3T detects level of GluR1 & has been published & validated for use in IH, IP & WB.
merck millipore,默克密理博,04-855,Anti-GluR1 Antibody, clone C3T, rabbit monoclonal
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Chp, H, M, R WB, IHC Rb Culture Supernatant Monoclonal Antibody 描述 产品目录编号 04-855 Replaces 05-855 品牌系列 Upstate
商名 - Upstate
描述 Anti-GluR1 Antibody, clone C3T, rabbit monoclonal 背景信息 L glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors that have been divided into 3 groups. Group I includes GRM1 and these receptors have been shown to activate phospholipase C. GRM1 expression has been reported in various regions of the brain and spinal cord. ESTs have been isolated from brain and eye libraries. 产品信息 格式 Culture Supernatant 控制 - Routinely evaluated by immunoblot on rat brain microsomal preparation (12-144)
演示 Cultured supernantant in 0.05% sodium azide 应用 应用 Anti-GluR1 Antibody, clone C3T detects level of GluR1 & has been published & validated for use in IH, IP & WB. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Western Blot Analysis:
A 1:5,000-1:10,000 dilution of this lot detected GluR1 from a rat brain microsomal preparation (Catalog # 12-144).
Immunoprecipitation: 2 μL of a previous lot immunoprecipitated GluR1 from rat brain microsomal preparation.
Immunohistochemistry: A previous lot of this antibody has been shown to detect GluR1 in human, mouse and rat tissues.
生物信息 免疫原品种 KLH-conjugated, synthetic peptide corresponding to amino acids 858-868 (..TLPRNSGAGAS..) of human GluR1 (amino acids 840-850 of mature human GluR1) 克隆 C3T 宿主 Rabbit 特异性 Recognizes GluR1, Mr 106 kDa. 同种型 IgG 品种反应性 ChimpanzeeHumanMouseRat Species Reactivity Note Rat. Predicted to cross-react with human, mouse and chimpanzee. 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000827.2
Entrez基因汇总 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. 基因符号 - GluR-1
- GLUR1
- GluR-K1
- GLURA
- HBGR1
- GLUH1
- MGC133252
- GRIA1
- GluR-A
UniProt编号 - P42261
UniProt汇总 FUNCTION: SwissProt: P42261 # Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
SIZE: 906 amino acids; 101506 Da
SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Interacts with CACNG2 and RASGRF2 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Interaction with CACNG2 promotes cell surface expression (By similarity).
TISSUE SPECIFICITY: Widely expressed in brain.
PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
SIMILARITY: SwissProt: P42261 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.产品使用声明 质量保证 Routinely evaluated by immunoblot on rat brain microsomal preparation (12-144). 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 100 µL
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下一件merck millipore产品：merck millipore,默克密理博,MAB1965,Anti-Integrin β1 Antibody, a.a. 82-87, clone JB1A (a.k.a. J10)
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