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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE605 描述 Anti-TREX1 Antibody Alternate Names - DNase III
- Three prime repair exonuclease 1
- CRV
- AGS1
- DRN3
- HERNS
- 3'-5' exonuclease TREX1
背景信息 TREX1, (DNase III), or three prime repair exonuclease 1 is the major 3’→ 5’ DNA exonuclease in mammalian cells. TREX1 binds preferentially to ssDNA and can also remove mismatched 3’ terminal deoxyribonucleotides at DNA strand breaks. The protein is required for proper DNA checkpoint signaling and plays critical roles in DNA replication and gap filling during DNA repair. TREX1 has a perinuclear distribution in mammalian cells and is colocalized with ER-associated proteins in cells at rest. TREX1 relocalizes to the nucleus and specifically to replication forks during S phase and periods of DNA synthesis and repair such as after irradiation. TREX1 acts on an ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates and thus acts to attenuate DNA damage checkpoint signaling and prevent pathological immune activation in normal cells. Defects in TREX1 protein have been associated in humans with many inherited diseases including Aicardi-Goutiėres syndrome type 1 (AGS1), systemic lupus erythematosus (SLE), chilblain lupus type 1 (CHBL1), and vasculopathy, retinal, with cerebral leukodystrophy (RVCL). EMD Millipore’s Anti-TREX1 rabbit polyclonal antibody has been tested in western blotting, immunohistochemistry, and immunofluorescence in human samples. 产品信息 格式 Affinity Purified 控制 - Human spleen tissue lysate
演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Detect DNASE using this rabbit polyclonal antibody, Anti-TREX1 Antibody validated for use in western blotting, IHC & Immunofluorescence. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected TREX1 in human spleen tissue.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected TREX1 in human spleen tissue.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human TREX1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human 抗体类型 Polyclonal Antibody 基因符号 - TREX1
纯化方法 Antigen Affinity purified UniProt编号 - Q9NSU2
产品使用声明 质量保证 Evaluated by Western Blotting in human spleen tissue lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected TREX1 in 15 µg of human spleen tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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