merck millipore,默克密理愽
  • merck millipore,默克密理博,MABF321,Anti-CD45 (mouse) Antibody, PE, clone 30-F11

  • merck millipore,默克密理博,MABF321,Anti-CD45 (mouse) Antibody, PE, clone 30-F11

    产品名称：Anti-CD45 (mouse) Antibody, PE, clone 30-F11
    产品型号：MABF321
    Anti-CD45 (mouse) Antibody, PE, clone 30-F11 is a highly specific rat monoclonal antibody, that targets CD45 & has been tested in Flow Cytometry, IHC, Activity Assay, IP & western blotting.

    merck millipore,默克密理博,MABF321,Anti-CD45 (mouse) Antibody, PE, clone 30-F11

  • 产品介绍
  • merck millipore,默克密理博,MABF321,Anti-CD45 (mouse) Antibody, PE, clone 30-F11

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MWB, FC, IHC, ACTRPEMonoclonal Antibody
    描述
    产品目录编号 MABF321
    描述 Anti-CD45 (mouse) Antibody, PE, clone 30-F11
    Alternate Names
    • CD45
    • Receptor-type tyrosine-protein phosphatase C
    • Leukocyte common antigen
    • L-CA
    • T200
    背景信息 CD45, also known as PTPRC, is a receptor-tyrosine phosphatase required for antigen-induced signaling in T-cells and B-cells. CD 45 belongs to the protein-tyrosine phosphatase family, receptor class 1/6 subfamily.It also contains 2 fibronectin type-III domains and 2 tyrosine-protein phosphatase domains. CD45 has been shown to play an important role in T-cell activation through the antigen receptor. CD45 also is suggested to act as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one is suggested to affect the substrate specificity of the first domain. Upon T-cell activation, CD45 recruits and dephosphorylates SKAP1 and FYN. Furthermore, it has been shown to dephosphorylate LYN, and modulate LYN activity. Interestingly, CD45 has been associated with several Src-family tyrosine kinases, which are inhibited by tyrosine phosphorylation in their c-termini, suggesting a mechanism for signaling by CD45. CD45 has been shown to bind with GANAB and PRKCSH. Additionally, it interacts with SKAP1 and DPP4, whereas the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Mutations in CD45 have been associated with Multiple Sclerosis (MS) and severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.
    产品信息
    格式 PE
    演示 Purified rat conjugate antibody in buffer containing PBS (pH 7.2) with up to 0.1% sodium azide.
    应用
    应用 Anti-CD45 (mouse) Antibody, PE, clone 30-F11 is a highly specific rat monoclonal antibody, that targets CD45 & has been tested in Flow Cytometry, IHC, Activity Assay, IP & western blotting.
    主要应用
    • Western Blotting
    • Flow Cytometry
    • Immunohistochemistry
    • Activity Assay
    应用说明 Western Blotting Analysis: A representative lot detected human CD45 in Western Blotting. (Tsuboi S and Fukuda M. 1998)

    Immunohistochemistry Analysis: A representative lot detected human CD45 in Immunohistochemistry. (Simon DI, et al. 2000; Cornet A, et al. 2001)

    Immunoprecipitation Analysis: A representative lot detected human CD45 in Immunoprecipitation. (Ledbetter JA, et al. 1979)
    生物信息
    免疫原品种 Mouse thymus or spleen
    克隆 30-F11
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rat
    同种型 IgG2bκ
    品种反应性 Mouse
    Species Reactivity Note Mouse
    抗体类型 Monoclonal Antibody
    基因符号
    • CD45
    • PTPRC
    纯化方法 Affinity
    UniProt编号
    • P06800
    产品使用声明
    质量保证 The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

    Flow Cytometry Analysis: 0.25 μg of this antibody detected CD45 in one million C57BL/6 mouse splenocytes.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 The antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,MABF321,Anti-CD45 (mouse) Antibody, PE, clone 30-F11

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