merck millipore,默克密理愽
  • merck millipore,默克密理博,12-131,IGFBP-3

  • merck millipore,默克密理博,12-131,IGFBP-3

    产品名称：IGFBP-3
    产品型号：12-131
    IGFBP-3 primarily used in Affinity Binding Assays.

    merck millipore,默克密理博,12-131,IGFBP-3

  • 产品介绍

  • 重要规格表

    主要应用 品种
    ABAHuman
    描述
    产品目录编号 12-131
    品牌系列 Upstate
    商名
    • Upstate
    描述 IGFBP-3
    产品信息
    演示 Lyophilized powder
    应用
    应用 IGFBP-3 primarily used in Affinity Binding Assays.
    主要应用
    • Affinity Binding Assay
    生物信息
    品种 Human
    Entrez基因编号
    • NM_001013398.1
    • NM_000598.4
    Entrez基因汇总 This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
    基因符号
    • BP-53
    • IGFBP3
    • IBP3
    • IGFBP-3
    UniProt编号
    • P17936
    UniProt汇总 FUNCTION: SwissProt: P17936 # IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
    SIZE: 291 amino acids; 31674 Da
    SUBUNIT: Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN.
    SUBCELLULAR LOCATION: Secreted.
    TISSUE SPECIFICITY: Expressed by most tissues.
    DEVELOPMENTAL STAGE: IGFBP3 levels are higher during extrauterine life and peak during puberty.
    DOMAIN: SwissProt: P17936 The thyroglobulin type-1 domain mediates interaction with HN.
    SIMILARITY: Contains 1 IGFBP N-terminal domain. & Contains 1 thyroglobulin type-1 domain.
    产品使用声明
    质量保证 Routeinly evaluated in a binding activity assay by binding IGF-I.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Lyophilized: 2 years at 4°C. Rehydrated: 1 year at -20°C.
    包装信息
    数量 5 µg


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