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重要规格表
主要应用 Entrez基因编号 品种 Uni Prot编号 FUNC NM_002423.3 Human P09237 描述 产品目录编号 CC1057 Replaces AG905 品牌系列 Chemicon®
商名 - Chemicon
描述 MMP-7, human, recombinant 概述 MOLECULAR WT:
28,924 Daltons calculated from primary amino acid sequence.Alternate Names - Pro-matrilysin
产品信息 演示 Solution in 25 mM Tris-HCl (pH 7.5), 5 mM CaCl2, 0.15 M NaCl, 0.01% Brij35 0.02% NaN3 应用 主要应用 - Affects Function
生物信息 浓缩 0.1 mg/mL 纯度 ~ 70% when analyzed by SDS-PAGE followed by staining with CBB R-250. 来源 Recombinant from E. Coli 品种 Human 特异活性 SPECIFIC ACTIVITY: <br /><br />5453 U/mg <br /><br />One unit of enzyme activity is defined as the digestion of 1 micro g of Azocoll/min. at pH 7.5 and 37°C acetate. Entrez基因编号 - NM_002423.3
Entrez基因汇总 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. 基因符号 - EC 3.4.24.23
- MMP7
- MPSL1
- matrin
- MMP-7
- PUMP-1
- Matrin
- PUMP1
UniProt编号 - P09237
UniProt汇总 FUNCTION: SwissProt: P09237 # Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
COFACTOR: Binds 2 calcium ions per subunit. & Binds 2 zinc ions per subunit.
SIZE: 267 amino acids; 29677 Da
DOMAIN: SwissProt: P09237 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
SIMILARITY: Belongs to the peptidase M10A family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -80ºC for up to one year from date of receipt. 包装信息 数量 10 µg
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