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merck millipore,默克密理博,ABE159,Anti-acetyl-Histone H2B (Lys120) Antibody
产品名称：Anti-acetyl-Histone H2B (Lys120) Antibody
产品型号：ABE159
Anti-acetyl-Histone H2B (Lys120) Antibody is a rabbit polyclonal antibody for detection of acetyl-Histone H2B (Lys120) also known as Histone H2B type 1-D, Histone H2B.1 B, Histone H2B.b, H2B/b & has b More>>
merck millipore,默克密理博,ABE159,Anti-acetyl-Histone H2B (Lys120) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE159 描述 Anti-acetyl-Histone H2B (Lys120) Antibody Alternate Names - H2B/b
- Histone H2B type 1-D
- HIRA-interacting protein 2
- Histone H2B.1 B
- Histone H2B.b
背景信息 Histone H2B is one of four histones that form a core octameric structure required for the packaging of DNA into nucleosomes, the most basic level of chromatin arrangement. Histones undergo a number of post-translational modifications (PTM) at their N- and C-terminal tails which can influence chromatin structure and stability; and consequently, transcription, and DNA replication and repair. Acetylation is a reversible PTM that involves the transfer of acetyl groups to N-terminal lysine residues by a family of histone acetyltransferase enzymes, including GNAT, Gcn5, and p300/CBP. Histone acetylation reduces the electrostatic attractions between DNA and histones, which destabilizes chromatin structure and provide transcriptional complexes, for example, with access to DNA, potentially resulting in increased gene transcription. Lysine 120 of H2B (H2BK120) undergoes acetylation (by p300/CBP) and ubiquitination. Acetylation occurs first and is required for subsequent mono-ubiquitination. H2BK120 may function as a marker of “pre-active” chromatin, and is part of a complex regulatory system involving multiple histone modifications. 产品信息 格式 Affinity Purified 控制 - Untreated and sodium butyrate treated HeLa acid extract and recombinant Histone H2B
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-acetyl-Histone H2B (Lys120) Antibody is a rabbit polyclonal antibody for detection of acetyl-Histone H2B (Lys120) also known as Histone H2B type 1-D, Histone H2B.1 B, Histone H2B.b, H2B/b & has been validated in WB, IP, DB. 主要应用 - Western Blotting
应用说明 Immunoprecipitation Analysis: 10 mg from a representative lot immunoprecipitated acetyl-Histone H2B (Lys120) in 1 mg of sodium butyrate treated HeLa acid extract.
Dot Blot (Specificity) Analysis: A representative lot detected acetyl-Histone H2B (Lys120) peptides, but not unacetylated-histone H2B (Lys120) peptides or other peptides corresponding to modified histones.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of human Histone H2B acetylated at Lys120. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the C-terminus of Histone H2B acetylated at Lys120. 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_066407
基因符号 - HIRIP2
- HIST1H2BD
- H2BFB
纯化方法 Affinity purified UniProt编号 - P58876
产品使用声明 质量保证 Evaluated by Western Blot in untreated and sodium butyrate treated HeLa acid extract and in recombinant Histone H2B.
Western Blot Analysis: 0.1 mg/mL of this antibody detected acetyl-Histone H2B (Lys120) in 10 ng of untreated and sodium butyrate treated HeLa acid extract.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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