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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 36-005 品牌系列 Upstate
商名 - Upstate
描述 Anti-phospho-Bim EL (Ser55) Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%. 应用 应用 Anti-phospho-Bim EL (Ser55) Antibody is an antibody against phospho-Bim EL (Ser55) for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Peptide corresponding to amino acids 55-63 of human phospho-Bim EL (Ser55). 宿主 Rabbit 特异性 Bim EL phosphorylated on serine 55. 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_207002.2
- NM_138622.2
- NM_138623.2
- NM_138624.2
- NM_138626.2
- NM_138627.2
- NM_207003.1
- NM_006538.3
- NM_138621.3
Entrez基因汇总 The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. 基因符号 - BIM-alpha6
- BCL2L11
- BimL
- BIM
- BIM-beta7
- BOD
- BAM
- BimEL
- BIM-beta6
修改 - Phosphorylation
纯化方法 Protein A chromatography UniProt编号 - O43521
UniProt汇总 FUNCTION: SwissProt: O43521 # Induces apoptosis. Isoform BimL is more potent than isoform BimEL.
SIZE: 198 amino acids; 22171 Da
SUBUNIT: Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including Mcl-1, Bcl-2, Bcl-X(L), BFL-1, and BHRF1. Does not heterodimerize with proapoptotic proteins such as BAD, BOK, BAX or BAK (By similarity).
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Note=Associated with intracytoplasmic membranes (By similarity).
DOMAIN: SwissProt: O43521 The BH3 motif is required for Bcl-2 binding and cytotoxicity.
SIMILARITY:产品使用声明 质量保证 Routinely evaluated by immunoblot on phosphorylated Bim-GST. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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