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  • merck millipore,默克密理博,07-867,Anti-phospho-PKA catalytic subunits α/β (Thr197) Antibody

  • merck millipore,默克密理博,07-867,Anti-phospho-PKA catalytic subunits α/β (Thr197) Antibody

    产品名称：Anti-phospho-PKA catalytic subunits α/β (Thr197) Antibody
    产品型号：07-867
    Anti-phospho-PKA catalytic subunits α/β (Thr197) Antibody is an antibody against phospho-PKA catalytic subunits α/β (Thr197) for use in WB.

    merck millipore,默克密理博,07-867,Anti-phospho-PKA catalytic subunits α/β (Thr197) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-867,Anti-phospho-PKA catalytic subunits α/β (Thr197) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-867
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-PKA catalytic subunits α/β (Thr197) Antibody
    Alternate Names
    • PRKACA, PRKACB, PKA C-alpha/beta, cAMP-dependent protein kinase catalytic subunit alpha/beta, protein kinase A
    • PRKACA
    • PRKACB
    • PKA C-alpha/beta
    • cAMP-dependent protein kinase catalytic subunit alpha/beta
    产品信息
    格式 Affinity Purified
    演示 100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg2+ and Ca2+), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide).
    应用
    应用 Anti-phospho-PKA catalytic subunits α/β (Thr197) Antibody is an antibody against phospho-PKA catalytic subunits α/β (Thr197) for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Peptide corresponding to amino acid region encompassing the human, mouse, rat, cow, pig, and frog phospho-PKA α/β (Thr197).
    宿主 Rabbit
    特异性 Recognizes phospho- PKA α/β (Thr197)
    同种型 IgG
    品种反应性 Mouse
    Species Reactivity Note Predicted to react with human and rat based on complete sequence similarity.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_207518.1
    • NM_002730.3
    Entrez基因汇总 cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
    基因符号
    • PKACA
    • PRKACA
    • MGC102831
    • MGC48865
    修改
    • Phosphorylation
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P17612
    UniProt汇总 FUNCTION: SwissProt: P17612 # Phosphorylates a large number of substrates in the cytoplasm and the nucleus.
    SIZE: 351 amino acids; 40590 Da
    SUBUNIT: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.
    SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity).
    TISSUE SPECIFICITY: Isoform 2 is sperm specific.
    PTM: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (By similarity).
    SIMILARITY: SwissProt: P17612 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -80°C.
    Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -80°C. Avoid repeated freeze/ thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-867,Anti-phospho-PKA catalytic subunits α/β (Thr197) Antibody

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