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品种反应性 主要应用 宿主 格式 抗体类型 H ICC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC833 描述 Anti-TRIM25 Antibody Alternate Names - Zinc finger protein 147
- E3 ubiquitin/ISG15 ligase TRIM25
- Estrogen-responsive finger protein
- RING finger protein 147
- Tripartite motif-containing protein 25
- Ubiquitin/ISG15-conjugating enzyme TRIM25
背景信息 E3 ubiquitin/ISG15 ligase TRIM25, also known as Estrogen-responsive finger protein or RING finger protein 147 or Tripartite motif-containing protein 25 or Ubiquitin/ISG15-conjugating enzyme TRIM25 or Zinc finger protein 147, and encoded by the gene name TRIM25 or EFP or RNF147 or ZNF147, is a member of the RING finger-B box-coiled coil family and is a downstream target of estrogen receptor α. Mice lacking this gene displayed an underdeveloped uterus and reduced estrogen responsiveness demonstrating that this protein is essential for estrogen dependent proliferation. TRIM25 expression is increased in breast carcinoma where it promotes the growth of breast tumor by functioning as an E3 ubiquitin ligase that targets the negative cell cycle checkpoint 14-3-3s. Recent reports have indicated that TRIM25 E3 ubiquitin ligase is essential for the retinoic-acid-inducible gene 1 (RIG-1) signaling pathway to elicit host antiviral innate immunity. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Anti-TRIM25 Antibody is an antibody against TRIM25 for use in western blotting & ICC. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: 20 μg/mL from a representative lot detected TRIM25 in HeLa cells. 生物信息 免疫原品种 KLH-conjugated synthetic peptide corresponding to the C-terminus of human TRIM25. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human 抗体类型 Polyclonal Antibody 基因符号 - ZNF147
- TRIM25
- EFP
- RNF147
纯化方法 Affinity UniProt编号 - Q14258
产品使用声明 质量保证 Evaluated by Western Blotting in HeLa cell lysate with and without blocking peptide.
Western Blotting Analysis: 1 μg/mL of this antibody detected TRIM25 in HeLa cell lysate with and without blocking peptide.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,341280,Factor I, Human
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