merck millipore,默克密理博,328000,ERK Activation Inhibitor Peptide I, Cell-Permeable

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Merck Millipore 默克密理愽

merck millipore,默克密理博,328000,ERK Activation Inhibitor Peptide I, Cell-Permeable - Calbiochem

经验配方
C₈₆H₁₅₃N₁₉O₁₇S

描述
概述	A cell-permeable and reversible stearated 13-amino acid peptide corresponding to the N-terminus of MEK1 (MAPKK) that acts as a specific inhibitor of ERK activation and blocks the transcriptional activity of Elk1. Selectively binds to ERK2 and prevents its interaction with MEK (IC₅₀ = 2.5 µM). Potently blocks ERK activation in PMA-stimulated NIH 3T3 cells and NGF-treated PC12 cells (IC₅₀ = 13 µM). Does not affect the activation of JNKs or p38.
产品目录编号	328000
品牌系列	Calbiochem®
同义词	Ste-MEK1₁₃, Ste-MPKKKPTPIQLNP-NH₂, Erk Inhibitor IV

参考
参考	Kelemen, B.R., et al. 2002. J. Biol. Chem. 277, 8741.

产品信息
具有ATP竞争性	N
形式	White lyophilized solid
配方	Supplied as a trifluoroacetate salt.
Hill配方	C₈₆H₁₅₃N₁₉O₁₇S
化学配方	C₈₆H₁₅₃N₁₉O₁₇S
Molar Mass	1757.3
吸湿	Hygroscopic
肽序列	Ste-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH₂ (Ste = stearated)
可逆	Y

理化信息
细胞可渗透	Y
溶解度	DMSO or H₂O
肽序列	Ste-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH₂ (Ste = stearated)

储存和货运信息
货运代码	Blue Ice Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,328000,ERK Activation Inhibitor Peptide I, Cell-Permeable - Calbiochem

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