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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-689 Replaces 07-400 品牌系列 Upstate
商名 - Upstate
描述 Anti-EZH2 Antibody Alternate Names - Enhancer of Zeste Homologue 2
- KMT6
- Enx1
背景信息 Polycomb protein group complexes are responsible for the regulation of hundreds of genes in mammals and insects. These proteins are responsible for the assembly and packaging of chromatin and for the induction of methylation on Histone H3. EZH2 (enhancer of zeste homologue 2) is a member of the polycomb group of proteins and is involved in cell cycle regulation. EZH2 represses transcription via trimethylation of histone H3 on Lys27 (H3K27) as indicated by the fact that RNAi-mediated knockdown of EZH2 resulted in a loss of H3K27 trimethylation. The expression of this protein in human tumors is aggressive for hormone refractory prostate cancer. In breast cancer EZH2 expression was increased in malignant tumors and promoted anchorage independent and invasive growth in vitro. 产品信息 格式 Serum 控制 - K562 cell lysate, C2C12 cell lysate
应用 应用 This Anti-EZH2 Antibody is validated for use in Immunoprecipitation and Western Blotting and ChIP-seq for the detection of EZH2. 主要应用 - Western Blotting
生物信息 免疫原品种 His-tagged fusion protein corresponding to residues 1-343 of mouse enhancer of Zeste homolog 2 (EZH2) 宿主 Rabbit 特异性 EZH2 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_152998.1
- NM_004456.3
Entrez基因汇总 This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Two transcript variants encoding distinct isoforms have been identified for this gene. 基因符号 - ENX-1
- EZH2
- MGC9169
纯化方法 Antiserum UniProt编号 - Q15910
UniProt汇总 FUNCTION: SwissProt: Q15910 # May be involved in the regulation of gene transcription and chromatin structure.
SIZE: 746 amino acids; 85363 Da
SUBUNIT: Binds ATRX via the SET domain (Probable).
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Expressed in many tissues.
SIMILARITY: SwissProt: Q15910 ## Belongs to the EZ family. & Contains 1 SET domain.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from HeLa and C2C12 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 stable for 2 years at -20°C from date of shipment 包装信息 数量 200 µL
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