merck millipore,默克密理博,ABC767,Anti-PARP-3 Antibody

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merck millipore,默克密理博,ABC767,Anti-PARP-3 Antibody
产品名称：Anti-PARP-3 Antibody
产品型号：ABC767
Detect PARP using this rabbit polyclonal antibody, Anti-PARP Antibody3 validated for use in western blotting, IHC & Immunofluorescence.

merck millipore,默克密理博,ABC767,Anti-PARP-3 Antibody

产品介绍

merck millipore,默克密理博,ABC767,Anti-PARP-3 Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABC767
描述	Anti-PARP-3 Antibody
Alternate Names	PARP3 Poly [ADP-ribose] polymerase 3 PARP-3 hPARP-3 ADP-ribosyltransferase diphtheria toxin-like 3 ARTD3 IRT1 NAD(+) ADP-ribosyltransferase 3 ADPRT-3 Poly[ADP-ribose] synthase 3 pADPRT-3
背景信息	PARP3, or Poly ADP ribose polymerase 3, also known as ADP-ribosyltransferase diphtheria toxin-like-3 (ARTD3), IRT1, NAD(+) ADP-ribosyltransferase 3 (ADPRT-3), Poly-ADP-ribose-synthase 3 (pADPRT-3) and encoded by the human gene named PARP3/ADPRT3/ADPRTL3 is a key enzyme involved in DNA repair and surveillance. PARP3 catalyzes the poly ADP-ribosylation of a limited number of acceptor targets that are involved in chromatin architecture and DNA metabolism; the modification by PARP3 is required for proper recognition of DNA damage and appears to be an enzymatic from DNA surveillance and mitotic fidelity checkpoint. PARP3 interacts with several proteins including PARP1, PRKDC, and XRCC5 and PARP3 is a component of the centrosome as well. PARP3 is localized primarily in the nucleus except during times of cell division. PRAP3 is expressed in all tissues with the highest levels being in the kidney, skeletal muscle and heart. Moreover different family members play different DNA repair roles in the cell. Recent research demonstrates that PARP3 is active in the efficient joining of DNA double-strand breaks during non-homologous end-joining whereas PARP1 modulates UV mediated DNA damage, and PARP3 has been identified as a critical player in the stabilization of the mitotic spindle and in telomere integrity notably by associating and regulating the mitotic components NuMA and tankyrase 1 and thus is a target for cancer therapy as well. Interestingly too, PARP3 is also implicated in ADP ribosylation of key signaling molecules in other cellular systems such as energy metabolism, neural crest development and memory. EMD-Millipore’s Anti-PARP3 rabbit polyclonal antibody has been tested in western blot on human kidney tissue lysates and in paraffin embedded immunohistochemistry on human pancreatic cancer tissue sections and in fluorescent immunocytochemistry on HeLa cells in culture.

产品信息
格式	Affinity Purified
演示	Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide and 50% glycerol.

应用
应用	Detect PARP using this rabbit polyclonal antibody, Anti-PARP Antibody3 validated for use in western blotting, IHC & Immunofluorescence.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected PARP3 in human pancreas cancer tissue. Immunofluorescence Analysis: A 1:25 dilution from a representative lot detected PARP3 in HeLa cells.

生物信息
免疫原品种	GST-tagged fusion protein corresponding to human PARP3.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
品种反应性	Human
抗体类型	Polyclonal Antibody
基因符号	ADPRTL3 PARP3 ADPRT3
纯化方法	Antigen Affinity purified
UniProt编号	Q9Y6F1

产品使用声明
质量保证	Evaluated by Western Blotting in human kidney tissue lysate. Western Blotting Analysis: A 1:800 dilution of this antibody detected PARP3 in human kidney tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.