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merck millipore,默克密理博,FCMAB228F,Milli-Mark™ Anti-mouse CD45R (B220)-FITC Antibody, clone RA3-3A1/6.1
产品名称：Milli-Mark™ Anti-mouse CD45R (B220)-FITC Antibody, clone RA3-3A1/6.1
产品型号：FCMAB228F
Milli-Mark Anti-mouse CD45R (B220)-FITC Antibody, clone RA3-3A1/6.1 is an antibody against mouse CD45R (B220) for use in FC.
merck millipore,默克密理博,FCMAB228F,Milli-Mark™ Anti-mouse CD45R (B220)-FITC Antibody, clone RA3-3A1/6.1
- 产品介绍
- merck millipore,默克密理博,FCMAB228F,Milli-Mark™ Anti-mouse CD45R (B220)-FITC Antibody, clone RA3-3A1/6.1
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M FC R FITC Monoclonal Antibody 描述 产品目录编号 FCMAB228F 商名 - Milli-Mark
描述 Milli-Mark™ Anti-mouse CD45R (B220)-FITC Antibody, clone RA3-3A1/6.1 Alternate Names - T200
- Receptor-type tyrosine-protein phosphatase C
- Leukocyte common antigen
- L-CA
- Lymphocyte antigen 5
- Ly-5
背景信息 The interleukin-2 receptors consist of three polypeptides (α, β, γ), which in different combinations bind IL-2 (Ishii, 1995). The 55 kDa α-chain is called CD25. CD25 is strongly expressed on the surface of activated T cells (Uchiyama, 1981), and is also expressed on B cells stimulated with anti-IgM antibody, and on monocytes/macrophages stimulated with lipopolysaccharide (Sugamura, 1997). In normal peripheral blood a variable expression on lymphoid cells (about 3-25%) is observed. The specificity of Anti-CD25, ACT-1, is identical to that of CD25-clustered antibodies (Schwarting, 1987; Aziz, 1996). 产品信息 格式 FITC 控制 - Mouse splenocytes
演示 Purified rat monoclonal IgM conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 应用 Milli-Mark Anti-mouse CD45R (B220)-FITC Antibody, clone RA3-3A1/6.1 is an antibody against mouse CD45R (B220) for use in FC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Animals were immunized with the mouse cell line RAW 112. Spleen cells were fused with the S194/5.XX0.BU.1 myeloma. 克隆 RA3-3A1/6.1 宿主 Rat 特异性 Antibody recognizes CD45 isoform 1 also known as B220. 同种型 IgMκ 品种反应性 Mouse Species Reactivity Note Tested and passed on Mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001104786
基因符号 - Ly-5
- Ptprc
纯化方法 Ion Exchange UniProt编号 - P06800
UniProt汇总 FUNCTION: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN By similarity.
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
SUBUNIT STRUCTURE: Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes. Binds GANAB and PRKCSH.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Membrane raft. Note: Colocalized with DPP4 in membrane rafts.
DEVELOPMENTAL STAGE: Expression is restricted to the hematopoietic compartment of development.
DOMAIN: The first PTPase domain interacts with SKAP1
POST-TRANSLATIONAL MODIFICATION: Heavily N- and O-glycosylated.
SEQUENCE SIMILARITIES: Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. Contains 2 fibronectin type-III domains. Contains 2 tyrosine-protein phosphatase domains.产品使用声明 质量保证 Evaluated by flow cytometry using mouse splenocytes 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt. 包装信息 数量 100 tests
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