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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-249 品牌系列 Upstate
商名 - Upstate
描述 Anti-SMURF2 Antibody 产品信息 格式 Serum 演示 antiserum containing 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Detect SMURF2 with Anti-SMURF2 Antibody (Rabbit Polyclonal Antibody), that has been shown to work in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide corresponding to amino acids 161-174 (C-DGWEERRTASGRIQ) of human SMURF 2 宿主 Rabbit 特异性 SMURF 2 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_022739
基因符号 - hSMURF2
- SMURF2
- DKFZp686F0270
- MGC138150
纯化方法 Serum UniProt编号 - Q9HAU4
UniProt汇总 FUNCTION: SwissProt: Q9HAU4 # E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1, SMAD2 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
SIZE: 748 amino acids; 86196 Da
SUBUNIT: Interacts with SMAD1, SMAD2, SMAD3, SMAD6 and SMAD7 but not SMAD4.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Cytoplasmic in the presence of SMAD7.
TISSUE SPECIFICITY: Widely expressed.
DOMAIN:SwissProt: Q9HAU4 The second and third WW domains are responsible for interaction with R-SMAD (SMAD1, SMAD2 and SMAD3).
SIMILARITY: Contains 1 C2 domain. & Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. & Contains 3 WW domains.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from HepG2 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µL
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