- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC133 描述 Anti-NPC1 Antibody Alternate Names - Niemann-Pick C1 protein
背景信息 Niemann-Pick C1 protein (NPC1) functions as an intracellular cholesterol transporter. NPC1 acts in concert with NPC2 to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE)/ lysosomes to the ER and plasma membrane by an unknown mechanism. Cholesterol binds to NPC1 with the hydroxyl group buried in its binding pocket, but NPC1 binds oxysterol with higher affinity than cholesterol. NPC1 also has a possible role in vesicular trafficking in glia. NPC1 defects may cause Niemann-Pick disease type C1 (NPC1). 产品信息 格式 Affinity Purified 控制 - PC12 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect NPC using this rabbit polyclonal antibody, Anti-NPC1 Antibody validated for use in western blotting. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human NPC1. 表位 Cytoplasmic domain 宿主 Rabbit 特异性 This antibody recognizes the cytoplasmic domain of NPC1. 品种反应性 MouseRat Species Reactivity Note Demonstrated to react with Rat and Mouse. Predicted to react with Human based on 100% sequence homology. Other homologies: Bovine, Rabbit and Feline (92% sequence homology) and Porcine (85% sequence homology). 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_000262
基因符号 - NPC1
纯化方法 Affinity purified UniProt编号 - O15118
产品使用声明 质量保证 Evaluated by Western Blotting in PC12 cell lysate.
Western Blotting Analysis: A 1:500 dilution of this antibody detected NPC1 in 10 µg of PC12 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,MCH100108,Muse Caspase-3/7 Assay Kit
下一件merck millipore产品：merck millipore,默克密理博,481984,Nifuroxazide - CAS 965-52-6 - Calbiochem
相关产品
merck millipore,默克密理博,AB1722,Anti-Bcl-2 Antibody, a.a. 68-86 of mBCL2
merck millipore,默克密理博,12-354,Nitrotyrosine Immunoblotting Control
merck millipore,默克密理博,EZRGRT-91K,Rat/Mouse Ghrelin (total) ELISA
merck millipore,默克密理博,AB9466,Anti-PACAP Receptor Type 1 Antibody
merck millipore,默克密理博,MCH100108,Muse Caspase-3/7 Assay Kit
merck millipore,默克密理博,481984,Nifuroxazide - CAS 965-52-6 - Calbiochem
merck millipore,默克密理博,MAB2247-I,Anti-Integrin β1 Antibody, clone 12G10
