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merck millipore,默克密理博,324629,Eg5 Inhibitor VI - Calbiochem
产品名称：Eg5 Inhibitor VI - Calbiochem
产品型号：324629
The Eg5 Inhibitor VI controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications.
merck millipore,默克密理博,324629,Eg5 Inhibitor VI - Calbiochem
- 产品介绍
重要规格表
经验配方 C₁₃H₁₁F₃N₂O₂S 描述 概述 A cell-permeable biphenylsulfamide compound that acts as a potent, reversible, and ATP-competitive inhibitor of Eg5/KSP ATPase activity (IC50 = 18 nM) with reactivity against both wild-type and the D130V mutant (Ki = 6.2 nM and 7 nM, respectively) in cell-free assays. Due to a higher ATP binding affinity of the WT enzyme, the inhibitor exhibits a much weaker antiproliferative activity against WT-expressing cells in cultures (IC50 = 5.4 and 403 nM, using HCT116 D130V and HCT116, respectively) and its in vivo antitumor efficacy has only been demonstrated in HCT116 D130V xenografed mice, but not mice with WT KSP-bearing Colo205. 产品目录编号 324629 品牌系列 Calbiochem®
同义词 N-(4ʹ-(Trifluoromethyl)-4-biphenyl)sulfamide, KSP Inhibitor VI 参考 参考 Parrish, C.A., et al. 2007. J. Med. Chem. 50, 4939. 产品信息 形式 Off-white solid Hill配方 C₁₃H₁₁F₃N₂O₂S 化学配方 C₁₃H₁₁F₃N₂O₂S Molar Mass 316.3 结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO or EtOH 安全信息 R相 R: 22-36/38
Harmful if swallowed.
Irritating to eyes and skin.S相 S: 26-36-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Ambient Temperature Only
毒性 Harmful
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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