merck millipore,默克密理博,AB9748,Anti-14-3-3 pan Antibody

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merck millipore,默克密理博,AB9748,Anti-14-3-3 pan Antibody
产品名称：Anti-14-3-3 pan Antibody
产品型号：AB9748
Detect 14-3-3 pan using this Anti-14-3-3 pan Antibody validated for use in IP, WB, IH.

merck millipore,默克密理博,AB9748,Anti-14-3-3 pan Antibody

产品介绍

merck millipore,默克密理博,AB9748,Anti-14-3-3 pan Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
Rp, Am, Av, B, Ch, H, M, Pl, R, Sh, F	IHC, WB	Rb	Serum	Polyclonal Antibody

描述
产品目录编号	AB9748
Replaces	04-1089
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-14-3-3 pan Antibody
背景信息	Mammals express seven distinct 14-3-3 isoforms (gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo- and hetero- dimmers, thus rendering 14-3-3 as a key multifunctional regulatory molecule. 14-3-3 isomers have been implicated in several neurological disorders: for example isoforms gamma, epsilon and beta are expressed in the cerebrospinal fluid of Creutzfeldt-Jakob patients, but not patients suffering from other neurological conditions such as Alzheimer's. The 14-3-3 pan antibody is one of a panel of antibodies that were generated against 14-3-3 isoforms and have demonstrated their potential for use as an ELISA-based diagnostic tool. These antibodies will allow the research to investigate the role of this protein in key cellular processes and neurological disorders such as Creutzfeldt-Jakob, Alzheimer's and Parkinson's Disease.

产品信息
格式	Serum
演示	Liquid.

应用
应用	Detect 14-3-3 pan using this Anti-14-3-3 pan Antibody validated for use in IP, WB, IH.
主要应用	Immunohistochemistry Western Blotting
应用说明	Western blot: 1:1,000-1:2,000 using ECL. Immunohistochemistry Immunoprecipitation Optimal working dilutions must be determined by end user.

生物信息
免疫原品种	Synthetic peptide.
宿主	Rabbit
特异性	14-3-3 pan. By Western blot the antibody recognizes the ~30 kDa protein.
品种反应性	ReptileAmphibianAvianBovineChickenHumanMouseGreen PlantsRatSheepFish
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_006761.3
Entrez基因汇总	This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer.
基因符号	FLJ45465 YWHAE KCIP-1 MDS 14-3-3E MDCR
纯化方法	Serum
UniProt编号	P62258
UniProt汇总	FUNCTION: SwissProt: P62258 # Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. SIZE: 255 amino acids; 29174 Da SUBUNIT: Homodimer. Interacts with NDEL1 (By similarity). Interacts with HCV core protein. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. SIMILARITY: SwissProt: P62258 ## Belongs to the 14-3-3 family.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.

储存和货运信息

存储条件

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.