merck millipore,默克密理愽
  • merck millipore,默克密理博,616459,TGF-β RI Kinase Inhibitor VIII - CAS 356559-20-1 - Calbiochem

  • merck millipore,默克密理博,616459,TGF-β RI Kinase Inhibitor VIII - CAS 356559-20-1 - Calbiochem

    产品名称：TGF-β RI Kinase Inhibitor VIII - CAS 356559-20-1 - Calbiochem
    产品型号：616459
    The TGF-β RI Kinase Inhibitor VIII, also referenced under CAS 356559-20-1, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & De More>>

    merck millipore,默克密理博,616459,TGF-β RI Kinase Inhibitor VIII - CAS 356559-20-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,616459,TGF-β RI Kinase Inhibitor VIII - CAS 356559-20-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₁H₂₁N₅356559-20-1
    描述
    概述 A cell-permeable quinoxaline compound that acts as a potent, highly selective, ATP-competitive inhibitor against type I TGF-β receptor TβR-I/ALK5 (IC50 = 14.3 nM), while exhibiting 4-fold less potency toward ALK4 (IC50 = 58.5 nM) and little or no activity against ALK2/3/6 and a panel of 26 other commonly studied kinases (≤29% inhibition at 10 µM). Effectively blocks (by >95%) TGF-β1-induced Smad2/3 activation (2 µM in ELT-3 cultures) and nuclear localization (1 µM in RPTE cultures), as well as TGF-β1-dependent p3TP- and ARE-luciferase transcription (0.1 µM in HaCat cultures). SB-525334 is orally available and is shown to attenuate Bleomycin- and Puromycin-induced tissue fibrosis in mice and rats in vivo.
    产品目录编号 616459
    品牌系列 Calbiochem®
    同义词 SB-525334, 6-(2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl)-quinoxaline, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor VIII, ALK5 Inhibitor VIII
    参考
    参考 Higashiyama, H., et al. 2007. Exp. Mol. Pathol. 83, 39.
    Grygielko, E.T., et al. 2005. J. Pharmacol. Exp. Ther. 313, 943.
    产品信息
    CAS号 356559-20-1
    形式 Yellow solid
    Hill配方 C₂₁H₂₁N₅
    化学配方 C₂₁H₂₁N₅
    Molar Mass 343.4
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    安全信息
    R相 R: 22-36/37/38

    Harmful if swallowed.
    Irritating to eyes, respiratory system and skin.
    S相 S: 26

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°:C). Stock solution is stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,616459,TGF-β RI Kinase Inhibitor VIII - CAS 356559-20-1 - Calbiochem

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