merck millipore,默克密理愽
  • merck millipore,默克密理博,MABN389,Anti-Aggregated a-Synuclein Antibody, clone 5G4

  • merck millipore,默克密理博,MABN389,Anti-Aggregated a-Synuclein Antibody, clone 5G4

    产品名称：Anti-Aggregated a-Synuclein Antibody, clone 5G4
    产品型号：MABN389
    This Anti-Aggregated a-Synuclein Antibody, clone 5G4 is validated for use in western blotting, IHC & ELISA for the detection of Aggregated a-Synuclein.

    merck millipore,默克密理博,MABN389,Anti-Aggregated a-Synuclein Antibody, clone 5G4

  • 产品介绍
  • merck millipore,默克密理博,MABN389,Anti-Aggregated a-Synuclein Antibody, clone 5G4

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HELISA, WB, IHCMAffinity PurifiedMonoclonal Antibody
    描述
    产品目录编号 MABN389
    描述 Anti-Aggregated a-Synuclein Antibody, clone 5G4
    Alternate Names
    • NACP
    • Aggregated a-synuclein
    • Alpha-synuclein
    • Non-A beta component of AD amyloid
    • Non-A4 component of amyloid precursor
    背景信息 α-Synuclein, also known as Non-A beta component of AD amyloid or Non-A4 component of amyloid, or NACP, and encoded by the gene SNCA/NACP/PARK1, is a protein originally identified as non-Abeta component protein (NACP) in the amyloid enriched fraction isolated from Alzheimer’s brain tissue. α-Synuclein is expressed in neural tissue and non-neural tissues too. In neurons, α-Synuclein is localized to the nucleus, presynaptic termini and mitochondria of certain brain regions. α-Synuclein is a molecular chaperone that binds various proteins and compounds including synaptobrevin-2 protein and membrane phospholipids and is involved in vesicle trafficking and membrane transport within neurons. Natural, non-mutated α-Synuclein has autoproteolytic activity and naturally forms stable alpha helical tetramers. However, mutated α-Synuclein can aggregate to form insoluble pathological complexes such as Lewy Bodies inside neurons. Lewy Bodies also contain ubiquitin and it is thought that they are evidence of disrupted proteasome function with regards to α-synuclein but research is still continuing.
    Pepscan epitope mapping experiments showed that the epitope of 5G4 seems to be hidden inside full-length a-synuclein in aqueous solution, and this fact could depend on a specific conformation of the molecule. Thus, after conformational change, like b-sheet building, the binding structure of 5G4 may be accessible in biological samples.
    This antibody can be used as a sandwich ELISA pair with Cat. No. MABN633, Anti-a-Synuclein, clone 10D2.
    产品信息
    格式 Affinity Purified
    演示 Purified mouse monoclonal IgG1κ in buffer containing PBS without preservatives.
    应用
    应用 This Anti-Aggregated a-Synuclein Antibody, clone 5G4 is validated for use in western blotting, IHC & ELISA for the detection of Aggregated a-Synuclein.
    主要应用
    • ELISA
    • Western Blotting
    • Immunohistochemistry
    应用说明 Western Blotting Analysis: 2 µg/mL from a representative lot detected Aggregated a-Synuclein in human brain tissue lysate.

    ELISA Analysis: A representative lot from an independent laboratory detected Aggregated a-Synuclein in a sandwich ELISA with Cat. No. MABN633, Anti-a-Synuclein, clone 5G4 (Kovacs, G. G., et al. (2012). Acta Neuropathol. 123(1):37-50.).
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human Aggregated a-Synuclein.
    克隆 5G4
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_000336
    基因符号
    • PARK1
    • SNCA
    • NACP
    纯化方法 Affinity purified
    UniProt编号
    • P37840
    产品使用声明
    质量保证 Evaluated by Immunohistochemistry in brain tissue from a Parkinson's disease patient.

    Immunohistochemistry Analysis: A representative lot detected Aggregated a-Synuclein in brain tissue from a Parkinson's disease patient.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABN389,Anti-Aggregated a-Synuclein Antibody, clone 5G4

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