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merck millipore,默克密理博,MABN88,Anti-K+/Cl- Cotransporter (KCC2) Antibody, clone N1/12
产品名称：Anti-K+/Cl- Cotransporter (KCC2) Antibody, clone N1/12
产品型号：MABN88
Detect K+/Cl-Cotransporter (KCC2) using this Anti-K+/Cl-Cotransporter (KCC2) Antibody, clone N1/12 validated for use in IH.
merck millipore,默克密理博,MABN88,Anti-K+/Cl- Cotransporter (KCC2) Antibody, clone N1/12
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, R IHC M Purified Monoclonal Antibody 描述 产品目录编号 MABN88 描述 Anti-K+/Cl- Cotransporter (KCC2) Antibody, clone N1/12 Alternate Names - potassium-chloride transporter), member 5
- Electroneutral potassium-chloride cotransporter 2
- Erythroid K-Cl cotransporter 2
- Neuronal K-Cl cotransporter
- electroneural potassium-chloride cotransporter 2
- solute carrier family 12
背景信息 KCC2 is a member of the cation-chloride cotransporter gene family. It acts as a K-Cl cotransporter. KCCs normally lower intracellular chloride concentrations below the electrochemical equilibrium potential and depending on the chemical concentration gradients of potassium and chloride, KCC2 can operate as a net efflux or influx pathway. It is proposed to act as the main chloride extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain. KCC2 is expressed at high levels in neurons throughout the nervous system and immunofluorescence shows that the protein is localized at inhibitory synapses of the spinal cord. Studies in mice have shown that KCC2 reduces GABA's inhibitory signaling, resulting in motor defects, epilepsy, and anxiety-like behavior. 产品信息 格式 Purified 控制 - Rat cortex area A-3 tissue
演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Detect K+/Cl-Cotransporter (KCC2) using this Anti-K+/Cl-Cotransporter (KCC2) Antibody, clone N1/12 validated for use in IH. 主要应用 - Immunohistochemistry
应用说明 Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected KCC2 in rat hypothalamus tissue. 生物信息 免疫原品种 Recombinant protein corresponding to rat KCC2. 表位 Unknown 克隆 N1/12 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes KCC2 同种型 IgG2aκ 品种反应性 HumanRat Species Reactivity Note Demonstrated to react with rat. Shown by an independent laboratory to react in human and mouse tissue. (UC Davis/NIH NeuroMab Facility Department of Neurobiology, Physiology and Behavior) 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_599190
Entrez基因汇总 Neuronal specific potassium-chloride cotransporter isoform; may play a role in response to neuronal injury [RGD]. 基因符号 - KCC2
- SLC12A5
- KIAA1176
- hKCC2
纯化方法 Protein G UniProt编号 - Q63633
UniProt汇总 FUNCTION: Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl- homeostasis in neurons. Necessary for the ontogenic change in response to gamma-aminobutyric acid (GABA) from depolarization to hyperpolarization during neuronal development.
SUBUNIT STRUCTURE: Homomultimer and heteromultimer with other K-Cl cotransporters. Interacts with AP2A1 (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICTY: Highly expressed in brain. Not detected in other tissues. Highly expressed in pyramidal neurons and in neurons throughout the cortex, hippocampus, the granular layer of the cerebellum and in groups of neurons throughout the brainstem. Barely detectable in dorsal-root ganglions.
DEVELOPMENTAL STAGE: Detected in thalamus, but not in hippocampus and neocortex at E20. At birth barely detectable in hippocampus. Expression increases steeply from day 5 to day 9 and then stabilizes at adult levels.
SEQUENCE SIMILARITIES: Belongs to the SLC12A transporter family.产品使用声明 质量保证 Evaluated by Immunohistochemistry in rat cortex area A-3 tissue.
Immunohistochemistry Analysis: 1:300 dilution of this antibody detected KCC2 in rat cortex area A-3 tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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