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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB3610 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Survivin Antibody Alternate Names - TIAP
背景信息 Apoptosis is triggered by a variety of stimuli, including members of the Tumor Necrosis Factor (TNF) family, and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. One of these IAP proteins, Survivin/TIAP, interacts with the processed form of caspase-3 and has been shown to inhibit its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas. 产品信息 格式 Serum 演示 Serum with no preservatives 应用 应用 This Anti-Survivin Antibody is validated for use in WB, IP, IH for the detection of Survivin. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunoblotting: Recommended antibody dilution 1:3000-6000
Immunoprecipitation: Recommended antibody dilution 1:200
Immunohistochemisty: Recommended antibody dilution 1:1500
Optimal antibody dilutions must be determined by end-user.生物信息 免疫原品种 Recombinant, GST-tagged full length human Survivin 宿主 Rabbit 特异性 Detects mouse survivin/TIAP in an approximate 17 kDa band by western blot. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001168.2
- NM_001012270.1
- NM_001012271.1
Entrez基因汇总 This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. 基因符号 - EPR-1
- BIRC5
- IAP4
- survivin
- API4
- SVV
UniProt编号 - O15392
UniProt汇总 FUNCTION: SwissProt: O15392 # May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Interacts with tubulin. Inhibitor of caspase-3 and caspase-7. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Isoforms 2 and 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti- apoptotic effects when compared with the displayed wild-type isoform.
SIZE: 142 amino acids; 16390 Da
SUBUNIT: Homodimer. When phosphorylated, interacts with HBXIP; the resulting complex binds pro-caspase-9, as well as active caspase- 9, but much less efficiently. Component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B. Interacts with EVI5.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes.
TISSUE SPECIFICITY: Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.
DOMAIN: SwissProt: O15392 The BIR repeat is necessary and sufficient for HBXIP binding.
SIMILARITY: Belongs to the IAP family. & Contains 1 BIR repeat.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C for up to 6 months after date of receipt. 包装信息 数量 100 µL
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