- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB3887 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Cortactin Antibody Alternate Names - Oncogene EMS1
- Amplaxin
产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25M NaCl, with 0.1% sodium azide as a preservative. 应用 应用 Detect Cortactin using this Anti-Cortactin Antibody validated for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:1,000-1:2,000 (0.5-1.0 μg/mL).
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide corresponding to amino acids 214-228 of human Cortactin. The immunogen sequence is 100% identical in mouse, rat, zebra fish, and chicken. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Cortactin (EMS1). Cortactin is an 80-85 kDa actin-binding protein, which consists of a variety of protein domains. The functional nature of these domains, coupled with the presence of multiple consensus sites for phosphorylation by tyrosine and serine/threonine kinases, suggests that cortactin integrates activation of specific signaling pathways with cytoskeletal reorganization. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_138565.1
- NM_005231.2
Entrez基因汇总 This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene. 基因符号 - FLJ34459
- CTTN
- EMS1
- Amplaxin
- 1110020L01Rik
UniProt编号 - Q14247
UniProt汇总 FUNCTION: SwissProt: Q14247 # May contribute to the organization of cell structure. The SH3 motif may function as a binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.
SIZE: 550 amino acids; 61636 Da
SUBUNIT: Interacts with SHANK2 and SHANK3 via its SH2 domain. Also interacts with FGD1 (By similarity). Interacts with PLXDC2.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, ruffle (By similarity). Note=Associated with membrane ruffles and lamellipodia (By similarity).
SIMILARITY: SwissProt: Q14247 ## Contains 7 cortactin repeats. & Contains 1 SH3 domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8ºC in undiluted aliquots for up to one year from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,559309,PhosphoDetect™ Anti-SAPK/JNK (pThr¹⁸³, Tyr¹⁸⁵) Rabbit pAb
下一件merck millipore产品：merck millipore,默克密理博,05-466,Anti-GRK 4-6 Antibody, clone A16/17
相关产品
merck millipore,默克密理博,SF-1522,CELF1; Human, Cyanine 5 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,190080,AY 9944 - CAS 366-93-8 - Calbiochem
merck millipore,默克密理博,05-684,Anti-dimethyl-Histone H3 (Lys4) Antibody, clone RR302
merck millipore,默克密理博,554715,Retro-2 - Calbiochem
merck millipore,默克密理博,559309,PhosphoDetect™ Anti-SAPK/JNK (pThr¹⁸³, Tyr¹⁸⁵) Rabbit pAb
merck millipore,默克密理博,05-466,Anti-GRK 4-6 Antibody, clone A16/17
merck millipore,默克密理博,203701,bpV(HOpic) - Calbiochem
merck millipore,默克密理博,S7350,OxyICC™ Oxidized Protein Detection Kit
