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merck millipore,默克密理博,554715,Retro-2 - Calbiochem
产品名称：Retro-2 - Calbiochem
产品型号：554715
A cell-permeable tricyclic imine compound that inhibits the endosome-to-Golgi retrograde transport, but not cellular uptake, of CtxB, StxB without affecting cellular uptake/trafficking of Tf or EGF.
merck millipore,默克密理博,554715,Retro-2 - Calbiochem
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重要规格表
经验配方 C₁₉H₁₆N₂OS 描述 概述 A cell-permeable tricyclic imine compound that inhibits the endosome-to-Golgi retrograde transport, but not cellular uptake, of CtxB (Cholera toxin B chain), StxB (Shiga-like toxin B chain), and the plant toxin ricin from castor seed in HeLa cells (20 µM), without affecting cellular uptake and trafficking of Tf (Transferrin), EGF, and vesicular stomatitis virus glycoprotein VSVGts045. Retro-2 is demonstrated to selectively affect the cellular distribution of SNARE proteins Synt5 and Synt6, but not 24 other Golgi and endocytic pathway proteins. Retro-2 pretreatment is shown to effectively protect against ricin-, Stx1-, and Stx2-induced cytotoxicity in HeLa cultures in vitro (Fold of protection against 4 h toxin incubation = 2.7, 22, and 65, respectively, with 0.5 h 20 µM Retro-2 pretreatment), as well as ricin-induced (2 µg/kg by nasal spray) fatality in mice in vivo (0 mortality with one 200 mg/kg i.p. dose 1h prior to toxin exposure). 产品目录编号 554715 品牌系列 Calbiochem®
同义词 Cholera Toxin Retrograde Transport Blocker, Ricin Retrograde Transport Blocker, SLT Retrograde Transport Blocker, 2-(((5-Methyl-2-thienyl)methylene)amino)-N-phenylbenzamide 参考 参考 Stechmann, B., et al. 2010. Cell 141, 231. 产品信息 形式 Tan powder Hill配方 C₁₉H₁₆N₂OS 化学配方 C₁₉H₁₆N₂OS Molar Mass 320.4 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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