merck millipore,默克密理博,506350,Pam₃Cys-Ser-(Lys)₄, Hydrochloride

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merck millipore,默克密理博,506350,Pam₃Cys-Ser-(Lys)₄, Hydrochloride
产品名称：Pam₃Cys-Ser-(Lys)₄, Hydrochloride
产品型号：506350

merck millipore,默克密理博,506350,Pam₃Cys-Ser-(Lys)₄, Hydrochloride

产品介绍

merck millipore,默克密理博,506350,Pam₃Cys-Ser-(Lys)₄, Hydrochloride

描述
概述	A cell-permeable, water-soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide, and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2. Acts as a selective agonist of TLR2 (Toll-like receptor 2).
产品目录编号	506350
品牌系列	Calbiochem®
同义词	(S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys₄-OH, 3HCl, P₃CSK₄, 3HCl, Pam₃Cys-SK₄, 3HCl, TLR1/TLR2 Agonist I

参考
参考	Barrenschee, M., et al. 2010. PLoS One. 5, e13889. Zahringer, U., et al. 2008. Immunology. 213, 205. Toshchakov, V., et al. 2002. Nat. Immunol. 3, 392. Muller, M.R., et al. 2001. Immunology 103, 49. Vergne, I., and Cezanne, L. 1999. Eur. J. Biochem. 264, 369. Diaz-Guerra, M.J., et al. 1996. J. Biol. Chem. 271, 30114. Offermanns, S., et al. 1992. Biochem. J. 282, 551. Seifert, R., et al. 1990. Biochem. J. 267, 795. Hoffmann, P., et al. 1989. Biol. Chem. Hoppe. Seyler. 370, 575.

参考

Barrenschee, M., et al. 2010. PLoS One. 5, e13889.
Zahringer, U., et al. 2008. Immunology. 213, 205.
Toshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
Muller, M.R., et al. 2001. Immunology 103, 49.
Vergne, I., and Cezanne, L. 1999. Eur. J. Biochem. 264, 369.
Diaz-Guerra, M.J., et al. 1996. J. Biol. Chem. 271, 30114.
Offermanns, S., et al. 1992. Biochem. J. 282, 551.
Seifert, R., et al. 1990. Biochem. J. 267, 795.
Hoffmann, P., et al. 1989. Biol. Chem. Hoppe. Seyler. 370, 575.

产品信息
形式	Lyophilized solid
Hill配方	C₈₁H₁₅₆N₁₀O₁₃S • 3 HCl
化学配方	C₈₁H₁₅₆N₁₀O₁₃S • 3 HCl
Molar Mass	1619.6

生物信息
纯度	≥90% by HPLC

理化信息
溶解度	H₂O

储存和货运信息
货运代码	Blue Ice Only
毒性	Standard Handling
储存	-20°C
防潮	Protect from moisture
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.