merck millipore,默克密理愽
  • merck millipore,默克密理博,371957,Isogranulatimide - CAS 244148-46-7 - Calbiochem

  • merck millipore,默克密理博,371957,Isogranulatimide - CAS 244148-46-7 - Calbiochem

    产品名称：Isogranulatimide - CAS 244148-46-7 - Calbiochem
    产品型号：371957
    Isogranulatimide, also referenced under CAS 244148-46-7, modulates the biological activity of Chk1 and GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation a More>>

    merck millipore,默克密理博,371957,Isogranulatimide - CAS 244148-46-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,371957,Isogranulatimide - CAS 244148-46-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₅H₈N₄O₂244148-46-7
    描述
    概述 A cell-permeable alkaloid containing indole/maleimide/imidazole skeleton that acts as a potent, reversible and ATP-competitive inhibitor of Chk1 (IC50 = 100 nM) and GSK-3β (IC50 = 500 nM). Inhibits G2 DNA damage checkpoint-associated kinases, Chk2, Cdk1, and DNA-PK only at much higher concentrations (IC50 = 3 µM, 10 µM, and 10 µM, respectively). Only minimally affects the activities of a panel of 11 other kinases tested (IC50 ≥ 40 µM). When used in combination with γ-irradiation, it is also reported to selectively arrest the growth of MCF-7 cells lacking p53 function.
    产品目录编号 371957
    品牌系列 Calbiochem®
    同义词 IGR, Chk2 Inhibitor III, Chk1 Inhibitor III
    参考
    参考 Jiang, X., et al. 2004. Mol. Cancer Ther. 3, 1221.
    Roberge, M., et al. 1998. Cancer Res. 58, 5701.
    产品信息
    CAS号 244148-46-7
    具有ATP竞争性 Y
    形式 Dark red solid
    Hill配方 C₁₅H₈N₄O₂
    化学配方 C₁₅H₈N₄O₂
    Molar Mass 276.3
    可逆 Y
    结构配方图像
    生物信息
    主靶 Chk1
    主靶IC50 100 nM, 500 nM, against Chk1 and GSK-3β, respectively
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,371957,Isogranulatimide - CAS 244148-46-7 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,9010-OP,OmniPur TRICINE - CAS 1389475 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,MAB1982,Anti-Integrin α6 Antibody, clone MA6


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