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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABF124 描述 Anti-cGAS Antibody Alternate Names - Mab-21 domain-containing protein 1
- Cyclic GMP-AMP synthase
- cGAMP synthase
- cGAS
- h-cGAS
背景信息 Cyclic GMP-AMP synthase (cGAS), also known as cGAMP synthase, h-cGAS, Mab-21 domain-containing protein 1, and encoded by the gene name MB21D1 and C6orf150, is a member of the MAB-21 family. Cyclic GMP-AMP synthase (cGAS) is a nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. The catalysis process involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Recent studies have indicated that Cyclic GMP-AMP synthase (cGAS) has an antiviral activity by acting as a key cytosolic DNA sensor, when the presence of double-stranded DNA (dsDNA) in the cytoplasm acts as a danger signal that triggers the immune responses. Cyclic GMP-AMP synthase (cGAS) then binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. Cyclic GMP-AMP synthase (cGAS) is expressed in the monocytic cell line THP1. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-cGAS antibody is validated for use in Western Blotting for the detection of cGAS. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human cGAS near the C-terminus. 表位 Near C-terminus 浓缩 Please refer to lot specific datasheet. 宿主 Rabbit 品种反应性 MouseHuman Species Reactivity Note Human, Mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_612450
基因符号 - C6orf150
- MB21D1
纯化方法 Affinity purified UniProt编号 - Q8N884
产品使用声明 质量保证 Evaluated by Western Blotting in MDA-MB-231 cell lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected cGAS in 10 µg of MDA-MB-231 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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