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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ICC, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABT137 描述 Anti-ACF7/MACF1a Antibody Alternate Names - Trabeculin-alpha
- Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
- 620 kDa actin-binding protein
- ABP620
- Actin cross-linking family protein 7
- Macrophin-1
背景信息 Actin cross-linking family protein 7 (ACF7), also known as Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1a) exists as 5 different isoforms. Isoform 2, also known as MACF1a, serves as an F-actin-binding protein, which may play a role in cross-linking actin to other cytoskeletal proteins. In migrating cells, MACF1a localizes to the plasma membrane and ruffles in a GSK3-, Memo-, and APC-dependent manner. MACF1a localization is required for microtubule capture at the cell cortex downstream of ErbB2 signaling. Upon binding with AXIN1, beta-catenin, GSK3beta, and APC, MACF1a translocates this multi-complex from the cytoplasm to the cell membrane. MACF1a acts as a positive regulator of Wnt-induced TCF/beta-catenin-dependent transcriptional activation. It also plays an important role in wound healing, epidermal cellular migration, CNS development, and the polarization and coordinated movement of hair follicle stem cells. 产品信息 格式 Affinity Purified 控制 - Human melanoma and heart tissue
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-ACF7/MACF1a is an antibody targeting the ACF7/MACF1a protein, validated for use in IHC & ICC. 主要应用 - Immunocytochemistry
- Immunohistochemistry
应用说明 Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected ACF7/MACF1a in NIH/3T3 and HeLa cells. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human ACF7/MACF1a. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. Other Homologies: Bovine (75% sequence homology). 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_036222
基因符号 - ACF7
- MACF1
- ABP620
纯化方法 Affinity purified UniProt编号 - Q9UPN3-2
产品使用声明 质量保证 Evaluated by Immunohistochemistry in human melanoma and heart tissue.
Immunohistochemisty Analysis: A 1:250 dilution from a representative lot detected ACF7/MACF1a in human melanoma and heart tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,ABF124,Anti-cGAS Antibody
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