merck millipore,默克密理愽
  • merck millipore,默克密理博,07-363,Anti-AMPK α2 Antibody

  • merck millipore,默克密理博,07-363,Anti-AMPK α2 Antibody

    产品名称：Anti-AMPK α2 Antibody
    产品型号：07-363
    Detect AMPK α2 using this Anti-AMPK α2 Antibody validated for use in WB.

    merck millipore,默克密理博,07-363,Anti-AMPK α2 Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-363,Anti-AMPK α2 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 07-363
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-AMPK α2 Antibody
    Alternate Names
    • AMPK
    • AMP-Activated Protein Kinase
    产品信息
    格式 Purified
    控制
    • Rat liver preparation
    演示 Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
    应用
    应用 Detect AMPK α2 using this Anti-AMPK α2 Antibody validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 peptide corresponding to amino acids 353-367 (C-DDSAMHIPPGLKPHP) of human AMP-Activated Protein Kinase alpha2 (AMPKalpha2) catalytic subunit
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes AMP-Activated Protein Kinase alpha2 (AMPKα2).
    同种型 IgG
    品种反应性 RatHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_006252
    Entrez基因汇总 The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
    基因符号
    • PRKAA
    • PRKAA2
    • AMPK
    • AMPK2
    纯化方法 Protein A purfied
    UniProt编号
    • P54646
    UniProt汇总 FUNCTION: SwissProt: P54646 # Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.
    COFACTOR: Magnesium.
    SIZE: 552 amino acids; 62320 Da
    SUBUNIT: Heterotrimer of a catalytic subunit, a beta and a gamma non-catalytic subunits.
    SIMILARITY: SwissProt: P54646 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot in a rat liver preparation
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,07-363,Anti-AMPK α2 Antibody

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