merck millipore,默克密理愽
  • merck millipore,默克密理博,HTS060RTA,Ready-to-Assay™ V2 Vasopressin Receptor Frozen Cells

  • merck millipore,默克密理博,HTS060RTA,Ready-to-Assay™ V2 Vasopressin Receptor Frozen Cells

    产品名称：Ready-to-Assay™ V2 Vasopressin Receptor Frozen Cells
    产品型号：HTS060RTA
    Human V2 GPCR frozen cells for Calcium Flux FLIPR Assays.

    merck millipore,默克密理博,HTS060RTA,Ready-to-Assay™ V2 Vasopressin Receptor Frozen Cells

  • 产品介绍
  • merck millipore,默克密理博,HTS060RTA,Ready-to-Assay™ V2 Vasopressin Receptor Frozen Cells

    重要规格表

    应用说明 品种 宿主细胞 蛋白靶
    Calcium Flux AssaysHumanChem-1V2
    描述
    产品目录编号 HTS060RTA
    商名
    • Ready-to-Assay
    描述 Ready-to-Assay™ V2 Vasopressin Receptor Frozen Cells
    背景信息 Millipore’s Ready-to-Assay GPCR frozen cells are designed for simple, rapid calcium assays with no requirement for intensive cell culturing. Millipore has optimized the freezing conditions to provide cells with high viability and functionality post-thaw. The user simply thaws the cells and resuspends them in media, dispenses cell suspension into assay plates and, following over night recovery, assays for calcium response.

    Arginine vasopressin (AVP) is a 9 amino acid peptide that functions as an antidiuretic, vasoconstrictor and neurotransmitter. The three vasopressin receptors, V1A, V1B and V2, are GPCRs; V1A and V1B couple to Gq and calcium release, whereas V2 couples to Gs. V2 expressed in renal collecting ducts plays an important role in regulating renal free water excretion (Birnbaumer, 2000). Mutations in V2 result in X-linked nephrogenic diabetes insipidus, a syndrome in which the kidney is unable to concentrate urine, leading to dehydration and hypernatremia (Birnbaumer, 2001). Conversely, elevated levels of AVP lead to hyponatremia in the syndrome of inappropriate antidiuretic hormone secretion (SIADH), congestive heart failure or cirrhosis, and V2 selective antagonists have been developed to treat these conditions (Verbalis, 2002). Chemicon’s cloned human V2-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant V2 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between V2 and its ligands.
    产品信息
    部件
    • Fifty (50) mL of Media Component.
    • Pack contains 2 vials of mycoplasma-free cells, 1 ml per vial.
    检测方法 Fluorescent
    应用
    应用 Human V2 GPCR frozen cells for Calcium Flux FLIPR Assays.
    应用说明 Calcium Flux Assays
    生物信息
    品种 Human
    Entrez基因编号
    • NM_000054
    GPCR类别 A
    宿主细胞 Chem-1
    蛋白靶 V2
    靶子系列 Vasopressin
    细胞系类型
    • Ready-to-Assay
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    • This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck-Millipore to request certain information about you and the establishment where the GMOs are being handled.
    包装信息
    数量 1 kit

    merck millipore,默克密理博,HTS060RTA,Ready-to-Assay™ V2 Vasopressin Receptor Frozen Cells

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