• merck millipore,默克密理博,AB2974,Anti-phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) Antibody
  • merck millipore,默克密理博,AB2974,Anti-phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) Antibody

    产品名称:Anti-phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) Antibody
    产品型号:AB2974
    Anti-phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) Antibody is an antibody against phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) for use in WB, IC & IF.

    merck millipore,默克密理博,AB2974,Anti-phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB2974,Anti-phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Rhesus Macaque, HICC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB2974
    描述 Anti-phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) Antibody
    Alternate Names
    • NMMHC-IIA
    • MHA
    • FTNS
    • EPSTS
    • DFNA17
    • NMMHCA
    • MGC104539
    • NMHC-II-A
    • MYH9
    • Myosin-9
    • Cellular myosin heavy chain, type A
    • Myosin heavy chain 9
    • Myosin heavy chain, non-muscle Iia
    • Non-muscle myosin heavy chain A
    • NMMHC-A, Non-muscle myosin heavy chain Iia
    • NMMHC II-a
    背景信息 Myosin-2A heavy chain (MYH9) phosphorylation is known to be very important in regulating cell motility and chemotaxis. The suppression of myosin-2A heavy chain expression is strongly associated with osteoclast fusion and multinucleation. Recent research indicates that modifications in the myosin-IIA heavy chain could increase the risk of kidney disease. Myosin-2A heavy chain is shown to work with WAVE2 and is localized at the leading edge of the lamellipodia formation in cells.
    产品信息
    格式 Affinity Purified
    控制
    • Lambda phosphastase-untreated and lambda phosphastase-treated MDA-MB-468 cell lysates.
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) Antibody is an antibody against phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) for use in WB, IC & IF.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunofluorescence Analysis: A 1:400 dilution from a representative lot detected phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) in MDA-MB-231 cells. (Image courtesy of Anne R. Bresnick, Ph.D., Albert Einstein College of Medicine).

    Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) in MDA-MB-231 cells. (Image courtesy of Anne R. Bresnick, Ph.D., Albert Einstein College of Medicine).

    Western Blot Analysis: A previous lot of this antibody was used to detect phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) in conjunction with other associated proteins in multiple breast cancer cell lines. (Data courtesy of Anne R. Bresnick, Ph.D., Albert Einstein College of Medicine).
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human Myosin Heavy Chain 2A phosphorylated at Ser1943.
    表位 Phosphorylated Ser1943.
    宿主 Rabbit
    特异性 This antibody recognizes Myosin Heavy Chain 2A phosphorylated at Ser1943.
    品种反应性 Rhesus MacaqueHuman
    Species Reactivity Note Demonstrated to react with Human.
    Predicted to react with Rhesus Macaque based on 100% sequence homology. Other homologies: Canine (91% sequence homology), Porcine (90% sequence homology), and Rat and Mouse (80% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_002464
    Entrez基因汇总 This gene encodes a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain. The protein is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in MYH9 are the cause of non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness.
    基因符号
    • MYH9
    修改
    • Phosphorylation
    纯化方法 Affinity Purified
    UniProt编号
    • P35579
    UniProt汇总 FUNCTION: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.

    SUBUNIT STRUCTURE: Interacts with PDLIM2 By similarity. Interacts with SLC6A4 By similarity. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with SVIL.

    TISSUE SPECIFICITY: In the kidney, expressed in the glomeruli. Also expressed in leukocytes.
    产品使用声明
    质量保证 Evaluated by Western Blot in lambda phosphastase-untreated and lambda phosphastase-treated MDA-MB-468 cell lysates.

    Western Blot Analysis: 0.1 µg/mL of this antibody detected phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) in 10 µg of lambda phosphastase-treated MDA-MB-468 cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB2974,Anti-phospho-Myosin Heavy Chain 2A (MYH9) (Ser1943) Antibody

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