merck millipore,默克密理愽
  • merck millipore,默克密理博,14-546,G9a Protein, active, 50 µg

  • merck millipore,默克密理博,14-546,G9a Protein, active, 50 µg

    产品名称：G9a Protein, active, 50 µg
    产品型号：14-546
    Recombinant fusion protein containing amino acids 785-1210 of human G9a with an N-terminal GST tag. For use in Histone Methyltransferase Assays (HMT).

    merck millipore,默克密理博,14-546,G9a Protein, active, 50 µg

  • 产品介绍
  • merck millipore,默克密理博,14-546,G9a Protein, active, 50 µg

    重要规格表

    主要应用 Entrez基因编号 品种 Uni Prot编号
    HMTNM_025256.4, NM_006709.2HumanQ96KQ7
    描述
    产品目录编号 14-546
    品牌系列 Upstate
    商名
    • Upstate
    描述 G9a Protein, active, 50 µg
    概述 Recombinant fusion protein containing amino acids 785-1210 of human G9a with an N-terminal GST tag
    应用
    应用 Recombinant fusion protein containing amino acids 785-1210 of human G9a with an N-terminal GST tag. For use in Histone Methyltransferase Assays (HMT).
    主要应用
    • Histone Methyltransferase Assay (HMT)
    生物信息
    来源 expressed in E. coli
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_025256.4
    • NM_006709.2
    Entrez基因汇总 A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. This gene is found near this cluster; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair. These genes are all within the human major histocompatibility complex class III region. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but a recent publication shows that there is only a single gene. The protein encoded by this gene is thought to be involved in intracellular protein-protein interaction. There are three alternatively spliced transcript variants of this gene but only two are fully described.
    基因符号
    • FLJ35547
    • EHMT2
    • G9A
    • NG36/G9a
    • Em:AF134726.3
    • C6orf30
    • BAT8
    • NG36
    纯化方法 Glutathione agarose affinity chromatography
    UniProt编号
    • Q96KQ7
    UniProt汇总 FUNCTION: SwissProt: Q96KQ7 # Histone methyltransferase. Preferentially methylates 'Lys-9' of histone H3 and 'Lys-27' of histone H3 (in vitro). H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. Also methylates histone H1 (By similarity).
    SIZE: 1210 amino acids; 132370 Da
    SUBUNIT: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with GFI1B, WIZ and EHMT1.
    SUBCELLULAR LOCATION: Nucleus. Note=Associates with euchromatic regions. Does not associate with heterochromatin.
    TISSUE SPECIFICITY: Expressed in all tissues examined, with high levels in fetal liver, thymus, lymph node, spleen and peripheral blood leukocytes and lower level in bone marrow.
    DOMAIN:SwissProt: Q96KQ7 The SET domain mediates interaction with WIZ.
    PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
    SIMILARITY: Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. & Contains 7 ANK repeats. & Contains 1 post-SET domain. & Contains 1 pre-SET domain. & Contains 1 SET domain.
    产品使用声明
    质量保证 routinely evaluated by methylazation of core histones
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -20°C
    包装信息
    数量 50 µg

    merck millipore,默克密理博,14-546,G9a Protein, active, 50 µg

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