merck millipore,默克密理愽
  • merck millipore,默克密理博,14-810,UbcH5b Conjugating Enzyme, 100 µg

  • merck millipore,默克密理博,14-810,UbcH5b Conjugating Enzyme, 100 µg

    产品名称：UbcH5b Conjugating Enzyme, 100 µg
    产品型号：14-810
    The His6-tagged fusion protein of UbcH5b is charge & support ubiquitinylation in vitro. The His6-tagged UbcH5 family members all appear to form thiol ester conjugates with ubiquitin at a similar rate  More>>

    merck millipore,默克密理博,14-810,UbcH5b Conjugating Enzyme, 100 µg

  • 产品介绍
  • merck millipore,默克密理博,14-810,UbcH5b Conjugating Enzyme, 100 µg

    重要规格表

    Entrez基因编号 品种 Uni Prot编号
    NM_181838.1, NM_003339.2HumanP62837
    描述
    产品目录编号 14-810
    品牌系列 Upstate
    商名
    • Upstate
    描述 UbcH5b Conjugating Enzyme, 100 µg
    概述 The His6-tagged fusion protein of UbcH5b is charge and support ubiquitinylation in vitro. Unlike their GST-tagged counterparts, the His6-tagged UbcH5 family members all appear to form thiol ester conjugates with ubiquitin at a similar rate under similar conditions. The His-tagged version of this enzyme is not susceptible to self-ubiquitinylation. UbcH5b is highly homologous to the S. cerevisiae UbC4/5 family of E2 enzymes, demonstrated to be essential for degradation of regulatory and abnormal proteins. UbcH5b, together with UbcH5a and UbcH5c, are the most active class of E2 enzymes in cell extracts and are associated with regulation of a number of transcription factors including p53, NF-κB, and c-Fos.
    应用
    应用 The His6-tagged fusion protein of UbcH5b is charge & support ubiquitinylation in vitro. The His6-tagged UbcH5 family members all appear to form thiol ester conjugates with ubiquitin at a similar rate under similar conditions.
    生物信息
    纯度 >95% by SDS-PAGE
    来源 Recombinant human UbcH5b Conjugating Enzyme expressed in E. coli.
    品种 Human
    Entrez基因编号
    • NM_181838.1
    • NM_003339.2
    Entrez基因汇总 The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
    基因符号
    • UBC4
    • UBE2D2
    • UBCH5B
    • PUBC1
    • E2
    • UbcH5B
    • UBC4/5
    • E2(17)KB2
    UniProt编号
    • P62837
    UniProt汇总 FUNCTION: SwissProt: P62837 # Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53.
    SIZE: 147 amino acids; 16735 Da
    SUBUNIT: Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex.
    SIMILARITY: SwissProt: P62837 ## Belongs to the ubiquitin-conjugating enzyme family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -80°C from date of shipment. Avoid multiple freeze/thaw cycles. After initial defrost, aliquot into individual tubes and refreeze at -80°C.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,14-810,UbcH5b Conjugating Enzyme, 100 µg

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