- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,AB5905,Anti-Vesicular Glutamate Transporter 1 Antibody
产品名称：Anti-Vesicular Glutamate Transporter 1 Antibody
产品型号：AB5905
This Anti-Vesicular Glutamate Transporter 1 Antibody is validated for use in Immunohistochemistry for the detection of Vesicular Glutamate Transporter 1.
merck millipore,默克密理博,AB5905,Anti-Vesicular Glutamate Transporter 1 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R IHC Gp Serum Polyclonal Antibody 描述 产品目录编号 AB5905 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Vesicular Glutamate Transporter 1 Antibody Alternate Names - BNPI
- VGLUT1
背景信息 VGLUT1 is expressed in a subset of glutamate neurons and transports glutamate into native synaptic vesicles from the brain, exhibiting a conductance for chloride that is blocked by glutamate. Vesicular glutamate transport has a substantially lower apparent affinity than the plasma membrane excitatory amino acid transporters. Glutamate transport by VGLUT1 is saturated with a K(m) of approximately 2 mM, in the same range as transport by synaptic vesicles. Finally, plasma membrane glutamate transporters recognize both aspartate and glutamate as substrates, whereas VGLUT1 does not recognize aspartate. 产品信息 格式 Serum 控制 - Rat brain lysate
演示 Guinea pig Serum in 0.1% Sodium Azide. 应用 应用 This Anti-Vesicular Glutamate Transporter 1 Antibody is validated for use in Immunohistochemistry for the detection of Vesicular Glutamate Transporter 1. 主要应用 - Immunohistochemistry
应用说明 Immunohistochemistry: 1:5,000-1:10,000 using a cyanine conjugated secondary antibody.
Lightly fixed 4% PFA fixed materials are recommended. Enzymatic detection requires substantially higher primary antibody dilutions.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide from rat VGLUT1 protein with no overlap to VGLUT2. The immunogen is available as AG208. 浓缩 Variable 宿主 Guinea Pig 特异性 Recognizes Vesicular Glutamate Transporter 1 (VGLUT1, BNPI {Brain specific Na+ dependent inorganic phosphate cotransporter}). The antiserum has been tested on tissue sections from the rat central nervous system (CNS) using immunofluorescence histochemistry. The antiserum mainly labels nerve fibers and terminals. VGLUT1 is an excellent marker for glutamatergic nerve terminals. The staining pattern for the staining obtained with the VGLUT1 antiserum corresponds to the pattern described using other antisera to VGLUT1 (Bellocchio et al., 1998; Fremeau et al., 2001; Fujiyama et al., 2001; Sakata-Haga et al., 2001; Tong et al., 2001; Kaneko et al. 2002; Varoqui et al., 2002). Preabsorption of the VGLUT1 antiserum with immunogen peptide eliminates all immunostaining. 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_446311
Entrez基因汇总 a Na(+)-dependent inorganic phosphate cotransporter. 基因符号 - Bnpi
- VGluT1
- Solute carrier family 17 member 7
- Brain-specific Na(+)-dependent inorganic phosphate cotransporter
- Slc17a7
纯化方法 Unpurified UniProt编号 - Q62634
UniProt汇总 FUNCTION: SwissProt: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
SIZE: 560 amino acids; 61665 Da [MW of unprocessed precursor]
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome.
TISSUE SPECIFICITY: Expressed in the cerebellum, cerberal cortex and hippocampus. Isoform 2 is expressed specifically in retina.
SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 6 months at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 50 µL
上一件merck millipore产品：merck millipore,默克密理博,07-1227,Anti-PDE1B Antibody, Calmodulin-Dependent Phosphodiesterase 1B1
下一件merck millipore产品：merck millipore,默克密理博,PF124,ADAM10, His•Tag, Mouse, Recombinant, S. frugiperda
相关产品
merck millipore,默克密理博,MABN50A4,Anti-Olig2 Antibody, clone 211F1.1, Alexa Fluor488 Conjugate,MABN50A4
merck millipore,默克密理博,14-734M,FGFR1 (V561M) Protein, active, 250 µg
merck millipore,默克密理博,MABS477,Anti-LAP (TGF-β1) Antibody, clone TW4-6H10
merck millipore,默克密理博,AB2980,Anti-Tricellulin Antibody
merck millipore,默克密理博,07-1227,Anti-PDE1B Antibody, Calmodulin-Dependent Phosphodiesterase 1B1
merck millipore,默克密理博,PF124,ADAM10, His•Tag, Mouse, Recombinant, S. frugiperda
merck millipore,默克密理博,EZMIL4,Mouse IL-4 ELISA Kit, EZMIL4
merck millipore,默克密理博,04-381,Anti-MKK3 NT Antibody, rabbit monoclonal
