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品种反应性 主要应用 宿主 格式 抗体类型 Rb, B, Ca, H, Po ICC, ELISA, FC, WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB2081 Replaces 04-1123 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-CD44v3 Antibody, exon v3 产品信息 格式 Purified 演示 Purified IgG. Liquid in 10 mM sodium phosphate, 150 mM NaCl with 0.01% sodium azide. 应用 应用 Anti-CD44v3 Antibody, exon v3 detects level of CD44v3 & has been published & validated for use in ELISA, FC, IP, WB, IC, IH(P). 主要应用 - Immunocytochemistry
- ELISA
- Flow Cytometry
- Western Blotting
应用说明 ELISA
Flow Cytometry
Immunofluorescence
Immunohistostaining of paraffin embedded tissue
Immunoprecipitation
Western Blotting
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide of human CD44v3 表位 exon v3 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 CD44v3 (Approximant 200 kDa) 品种反应性 RabbitBovineCanineHumanPig 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001001392.1
- NM_000610.3
- NM_001001389.1
- NM_001001390.1
- NM_001001391.1
Entrez基因汇总 The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. 基因符号 - HCELL
- CD44
- LHR
- HUTCH-I
- CDW44
- CDw44
- ECMR-III
- Epican
- MGC10468
- CD44R
- MDU2
- PGP-1
- CSPG8
- Pgp1
- IN
- MUTCH-I
- MDU3
- MIC4
- MC56
UniProt编号 - P16070
UniProt汇总 FUNCTION: SwissProt: P16070 # Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
SIZE: 742 amino acids; 81554 Da
SUBUNIT: Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: An epithelial isoform (CD44E) is expressed by cells of epithelium and highly expressed by carcinomas. An hematopoietic isoform (CD44H) is expressed by cells of mesodermal origin. Expression is repressed in neuroblastoma cells.
PTM: Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors. & N-glycosylated. & O-glycosylated; contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). & Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
SIMILARITY: SwissProt: P16070 ## Contains 1 Link domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
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