merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5883,Anti-Synapsin I Antibody, phosphoSer 603

  • merck millipore,默克密理博,AB5883,Anti-Synapsin I Antibody, phosphoSer 603

    产品名称：Anti-Synapsin I Antibody, phosphoSer 603
    产品型号：AB5883
    Anti-Synapsin I Antibody, phosphoSer 603 detects level of Synapsin I & has been published & validated for use in WB.

    merck millipore,默克密理博,AB5883,Anti-Synapsin I Antibody, phosphoSer 603

  • 产品介绍
  • merck millipore,默克密理博,AB5883,Anti-Synapsin I Antibody, phosphoSer 603

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5883
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Synapsin I Antibody, phosphoSer 603
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin presented as a liquid in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
    应用
    应用 Anti-Synapsin I Antibody, phosphoSer 603 detects level of Synapsin I & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:1,000. Rat brain lysate shows a ~78-80kDa band.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to amino acids surrounding the phosphoSer603 of rat Synapsin I. The immunogen sequence is identical in human, mouse and Xenopus.
    表位 phosphoSer 603
    宿主 Rabbit
    特异性 Synapsin I, phosphoSer603. This is the site phosphorylated by Calcium calmodulin kinase II. The antibody recognizes the ~78 kD Synapsin I, phosphoSer603 protein. Immunolabeling is blocked by the immunogen peptide but no by the corresponding non-phospho peptide.
    品种反应性 Rat
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_133499.2
    • NM_006950.3
    Entrez基因汇总 This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
    基因符号
    • SYN1b
    • SYN1
    • SYN1a
    • Synapsin-1
    • SYNI
    修改
    • Phosphorylation
    UniProt编号
    • P17600
    UniProt汇总 FUNCTION: SwissProt: P17600 # Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
    SIZE: 705 amino acids; 74111 Da
    SUBUNIT: Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1 (By similarity).
    SUBCELLULAR LOCATION: Cell junction, synapse.
    PTM: Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.
    DISEASE:SwissProt: P17600 # Defects in SYN1 are a cause of X-linked recessive epilepsy associated with variable learning disabilities and behavior disorders [MIM:300491].
    SIMILARITY: SwissProt: P17600 ## Belongs to the synapsin family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB5883,Anti-Synapsin I Antibody, phosphoSer 603

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