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merck millipore,默克密理博,04-381,Anti-MKK3 NT Antibody, rabbit monoclonal
产品名称：Anti-MKK3 NT Antibody, rabbit monoclonal
产品型号：04-381
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-MKK3 NT Antibody detects level of MKK3 NT & has More>>
merck millipore,默克密理博,04-381,Anti-MKK3 NT Antibody, rabbit monoclonal
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, FC Rb Purified Monoclonal Antibody 描述 产品目录编号 04-381 品牌系列 Upstate
商名 - Upstate
描述 Anti-MKK3 NT Antibody, rabbit monoclonal Alternate Names - MAPKK3, MEK3, PRKMK3
- MAPKK3
- MEK3
产品信息 格式 Purified 控制 - POSITIVE: Jurkat, HeLa, MCF-7 or K562 cells.
演示 Rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 90 mM NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol. 应用 应用 Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-MKK3 NT Antibody detects level of MKK3 NT & has been published & validated for use in FC, IP & WB. 主要应用 - Western Blotting
- Flow Cytometry
应用说明 Western Blot: 1,5,000-1:20,000.
Immunoprecipitation: 1:50. The use of protein G agarose is recommended.
Flow Cytometry: 1:50.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 KLH-conjugated synthetic peptide corresponding to residues in the N-term of human MKK3. 表位 N-terminus 宿主 Rabbit 特异性 Recognizes MKK3 同种型 IgG 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_145109.2
- NM_145110.1
- NM_002756.3
Entrez基因汇总 The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. 基因符号 - MKK3
- MAP2K3
- MAPKK3
- PRKMK3
- MEK3
纯化方法 Protein G purfied UniProt编号 - P46734
UniProt汇总 FUNCTION: SwissProt: P46734 # Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.
SIZE: 347 amino acids; 39318 Da
SUBUNIT: Binds to DYRK1B/MIRK and increases its kinase activity. Part of a complex with MAP3K3, RAC1 and CCM2. Interacts with Yersinia yopJ.
TISSUE SPECIFICITY: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
PTM: Autophosphorylated. & Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity. & Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
DISEASE:SwissProt: P46734 # Defects in MAP2K3 may be involved in colon cancer.
SIMILARITY: SwissProt: P46734 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 Routinely evaluated by immunoblot analysis. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment. 包装信息 数量 100 µL
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