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- merck millipore,默克密理博,MABN50A4,Anti-Olig2 Antibody, clone 211F1.1, Alexa Fluor488 Conjugate,MABN50A4
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, R, M ICC M AlexaFluor®488 Monoclonal Antibody 描述 产品目录编号 MABN50A4 描述 Anti-Olig2 Antibody, clone 211F1.1, Alexa Fluor®488 Conjugate | MABN50A4 Alternate Names - Protein kinase C-binding protein RACK17
- Oligodendrocyte transcription factor 2
- Oligo2
- Class B basic helix-loop-helix protein 1
- bHLHb1
- Class E basic helix-loop-helix protein 19
- bHLHe19
- Protein kinase C-binding protein 2
背景信息 Oligodendrocyte lineage transcription factor 2 (Olig2) is a protein belonging to group A of the OLIG family of basic helix-loop-helix transcription factors (bHLH). bHLH proteins are divided into 6 groups (A-F), and characterized by their biochemical properties and structure. Olig2 is classified as group A due to its ability to form heterodimers with other bHLH proteins and binding to the E box. Olig2 has a crucial role during development in specifying the final location of motor neurons and oligodendrocytes in the spinal cord, along with the development within the hindbrain of somatic motor neurons. Olig2 expression is observed within oligodendrocytes and in developing astrocytes. Recent studies have shown strong expression of Olig2 in human oligodendrogliomas, primary tumors within the central nervous system, and moderate expression in astrocytomas. These observations have led to the proposal of Olig2 having potential as an oligodendroglioma diagnostic marker. 产品信息 格式 AlexaFluor®488 控制 - Rat oligodendrocyte precursor cells
演示 Purified mouse monoclonal IgG2a conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 主要应用 - Immunocytochemistry
生物信息 免疫原品种 Recombinant protein corresponding to human Olig2. 克隆 211F1.1 宿主 Mouse 同种型 IgG2a 品种反应性 HumanRatMouse Species Reactivity Note Demonstrated to react with mouse and rat. Predicted to react with human based on 100% sequence homology 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_005797
Entrez基因汇总 This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]. 基因符号 - RACK17
- OLIG2
- BHLHB1
- BHLHE19
- PRKCBP2
纯化方法 Protein G purified UniProt编号 - Q13516
UniProt汇总 FUNCTION: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity).
SIZE: 323 amino acids; 32385 Da
SUBUNIT: Interacts with NKX2-2 (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2 (By similarity).
TISSUE SPECIFICITY: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
DOMAIN: The bHLH is essential for interaction with NKX2-2 (By similarity).DISEASE:SwissProt: Q13516 # A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.
SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain.产品使用声明 质量保证 Evaluated by Immunocytochemistry in rat oligodendrocyte precursor cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Olig2 in rat oligodendrocyte precursor cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 µL
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