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merck millipore,默克密理博,MABS477,Anti-LAP (TGF-β1) Antibody, clone TW4-6H10
产品名称：Anti-LAP (TGF-β1) Antibody, clone TW4-6H10
产品型号：MABS477
Detect TGFβ using this mouse monoclonal antibody, Anti-LAP (TGF-β1) Antibody & clone TW4-6H10 validated for use in Flow Cytometry.
merck millipore,默克密理博,MABS477,Anti-LAP (TGF-β1) Antibody, clone TW4-6H10
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H FC M Purified Monoclonal Antibody 描述 产品目录编号 MABS477 描述 Anti-LAP (TGF-β1) Antibody, clone TW4-6H10 Alternate Names - TGFB
- Transforming growth factor beta-1
- TGF-beta-1
- Latency-associated peptide
- LAP
- TGFB1
背景信息 LAP, also known as TGF-beta1 or TGFB1, belongs to the TGF-beta family. TGFB1 is a multifunctional protein that controls proliferation, differentiation and other functions in various cell types. TGFB1 is synthesized by many cells that have specific receptors for it. It positively and negatively regulates many other growth factors. LAP TGF-beta1 plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. The 'straitjacket' and 'arm' domains encircle the growth factor monomers and are fastened together by strong bonding between Lys-56 and Tyr-103/Tyr-104. Activation of TGF-beta1 requires the binding of integrin alpha-V to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-beta binding proteins. The physical force unfastens the straitjacket and releases the active growth factor dimer. 产品信息 格式 Purified 演示 Purified mouse monoclonal IgG1κ antibody in buffer containing PBS (pH 7.2) with up to 0.1% sodium azide. 应用 应用 Detect TGFβ using this mouse monoclonal antibody, Anti-LAP (TGF-β1) Antibody & clone TW4-6H10 validated for use in Flow Cytometry. 主要应用 - Flow Cytometry
生物信息 免疫原品种 LAP (TGF-β) 克隆 TW4-6H10 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG1κ 品种反应性 Human 抗体类型 Monoclonal Antibody 基因符号 - TGFB
- TGFB1
纯化方法 Affinity UniProt编号 - P01137
产品使用声明 质量保证 Flow Cytometry Analysis: 1 μg of this antibody detected LAP (TGF-β1) in one million human peripheral blood mononuclear cells. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 The antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
包装信息 数量 100 µg
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