merck millipore,默克密理博,16-224,Anti-Myc Tag Antibody, clone 4A6, Alexa Fluor 488 conjugate

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merck millipore,默克密理博,16-224,Anti-Myc Tag Antibody, clone 4A6, Alexa Fluor 488 conjugate
产品名称：Anti-Myc Tag Antibody, clone 4A6, Alexa Fluor 488 conjugate
产品型号：16-224
Anti-Myc Tag Antibody, clone 4A6, Alexa Fluor 488 conjugate is an antibody against Myc Tag for use in IF, WB & IC.

merck millipore,默克密理博,16-224,Anti-Myc Tag Antibody, clone 4A6, Alexa Fluor 488 conjugate

产品介绍

merck millipore,默克密理博,16-224,Anti-Myc Tag Antibody, clone 4A6, Alexa Fluor 488 conjugate

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	ICC, WB	M	AlexaFluor®488	Monoclonal Antibody

描述
产品目录编号	16-224
品牌系列	Upstate
商名	Upstate
描述	Anti-Myc Tag Antibody, clone 4A6, Alexa Fluor® 488 conjugate

产品信息
格式	AlexaFluor®488

应用
应用	Anti-Myc Tag Antibody, clone 4A6, Alexa Fluor 488 conjugate is an antibody against Myc Tag for use in IF, WB & IC.
主要应用	Immunocytochemistry Western Blotting

生物信息
免疫原品种	KLH-conjugated, synthetic peptide corresponding to amino acids 410-420 (MEQKLISEEDL) of human Myc
克隆	clone 4A6
宿主	Mouse
特异性	Recognizes and is specific for recombinant proteins containing the Myc epitope tag (EQKLISEEDL) in a variety of sequence contexts. Also recognizes human Myc.
同种型	IgG
品种反应性	Human
Species Reactivity Note	Other species cross-reactivity not tested.
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_002467.3
Entrez基因汇总	The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
基因符号	c-Myc MYC C-MYC
UniProt编号	P01106
UniProt汇总	FUNCTION: SwissProt: P01106 # Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes. SIZE: 439 amino acids; 48804 Da SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with JARID1A and JARID1B. SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated by PRKDC. DISEASE: SwissProt: P01106 # Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. & A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1. SIMILARITY: SwissProt: P01106 ## Contains 1 basic helix-loop-helix (bHLH) domain.

产品使用声明
质量保证	Routinely evaluated by immunoblot and immunocytochemistry
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. Alexa Fluor® is a registered trademark of Molecular Probes, Inc.

产品使用声明

质量保证

Routinely evaluated by immunoblot and immunocytochemistry

使用声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc.