merck millipore,默克密理博,AB5847-25UL,Anti-Glutamate Receptor 1 Antibody, phosphoSer 831

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merck millipore,默克密理博,AB5847-25UL,Anti-Glutamate Receptor 1 Antibody, phosphoSer 831
产品名称：Anti-Glutamate Receptor 1 Antibody, phosphoSer 831
产品型号：AB5847-25UL
Anti-Glutamate Receptor 1 Antibody, phosphoSer 831 detects level of Glutamate Receptor 1 & has been published & validated for use in WB.

merck millipore,默克密理博,AB5847-25UL,Anti-Glutamate Receptor 1 Antibody, phosphoSer 831

产品介绍

merck millipore,默克密理博,AB5847-25UL,Anti-Glutamate Receptor 1 Antibody, phosphoSer 831

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	AB5847-25UL
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Glutamate Receptor 1 Antibody, phosphoSer 831
Alternate Names	GluR1

产品信息
格式	Affinity Purified
演示	Affinity purified immunoglobulin. Liquid in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.

应用
应用	Anti-Glutamate Receptor 1 Antibody, phosphoSer 831 detects level of Glutamate Receptor 1 & has been published & validated for use in WB.
主要应用	Western Blotting
应用说明	Western blot and dot blots: 1:1000. The working dilution should be based on the tissue and the expected phosphorylation state. Optimal working dilutions must be determined by the end user.

生物信息
免疫原品种	Synthetic peptide corresponding to amino acids surrounding the phosphoSer381 of rat GluR1.
表位	phosphoSer 831
宿主	Rabbit
特异性	Glutamate Receptor 1 [GluR1], phosphoSer831. The antibody recognizes a protein of 100 kDa corresponding to GluR1 phosphorylated at Ser831 in rat hippocampal homogenate.
品种反应性	RatHumanMouse
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_000827.2
Entrez基因汇总	Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
基因符号	MGC133252 GRIA1 GluR-K1 GLURA HBGR1 GluR-A GluR-1 GLUH1 GLUR1
修改	Phosphorylation
UniProt编号	P42261
UniProt汇总	FUNCTION: SwissProt: P42261 # Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. SIZE: 906 amino acids; 101506 Da SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Interacts with CACNG2 and RASGRF2 (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Interaction with CACNG2 promotes cell surface expression (By similarity). TISSUE SPECIFICITY: Widely expressed in brain. PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity). SIMILARITY: SwissProt: P42261 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family. MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer. During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.

储存和货运信息

存储条件

Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.

During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.